Group Zaborsky

Working Group:
immuno-oncology

Group leader:  Dr. rer. nat. Nadja Zaborsky

Cancer-immune interactions – to understand clonal evolution and anti-cancer immunity

Chronic lymphocytic leukemia (CLL), a very common B cell leukemia of the elderly is characterized by the accumulation of non-functional CD5 and CD19 double positive B cells in lymph nodes and peripheral blood. Recent high throughput sequencing approaches on multiple cancer entities revealed complex genetic landscapes in human cancers.  A complex set of clonal and subclonal mutations was also described for CLL. Overall, the interindividual genetic heterogeneity of CLL appeared larger than that observed in other hematopoietic cancers.

 

As mouse models have revealed many significant insights into tumor biology that have proven relevant to human disease, one focus of our group is to unravel the mutation profile in mouse and humen CLL to better understand etiology, development and progression of human disease. The Tcl1 transgenic (TCL1) mouse is the most widely used model to study biology and treatment response of CLL. Therefore we use the Tcl1 mouse model to dissect CLL-immune interactions in order to draw light on clonal evolution and immune interactions during disease progression. In a second step we want to find possibilities to reinvigorate anti-cancer immunity in CLL by phenotypic and functional characterization of tumor antigen specific T cells.

 

Another focus of our group is the gut microbiome and how it can modulate and can be modulated by the host immunity and we want to understand how the microbiome can influence the response and toxicity of immune therapies. In a collaboration project, we apply mathematical modeling to associate the microbiome and the immune cell  composition with clinical parameters and therapy response.

According to the current view, malignant cells are constantly interacting with immune cells, creating a reciprocal selective pressure that shapes subclonal cancer evolution and leads to specific skewing of the composition of immune cells deciding over success or failure of immunosurveillance and therapies (created with biorender).

“Investigating cancer-immune interactions are of utmost importance not only to understand cancer progression and immune evasion but also to improve current immune checkpoint therapy approaches, which – although considered as breakthrough in cancer therapy – fail to be effective in CLL and some other cancer entities.”

Team

Dr. Nadja Zaborsky
(Deputy Head of the LIMCR, Group leader)

Thomas Parigger, MSc
(PhD Student)

Aryunni Abu Bakar, MSc
(PhD Student)

Stephan Drothler, MSc.
(PhD Student)

Christian Scherhäufl, MSc.
(PhD Student)

Jan Höpner, MSc.
(PhD Student)

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