Group Hartmann

Working Group:
CLL Cell Trafficking and Microenvironment

Group leader: Assoc.-Prof. Dr. Tanja Hartmann

Emerging evidence suggests that a crosstalk of tumor cells with surrounding immune and accessory cells markedly contributes to the pathophysiology of B cell malignancies such as chronic lymphocytic leukemia (CLL). CLL is a dynamic disease characterized by a balance of cells circulating in the peripheral blood and cells located in supportive zones of lymphoid organs. Proliferation and survival of CLL cells depend on a complex interplay of distinct cell types, the extracellular matrix, and soluble factors within the organs, collectively referred to as the CLL microenvironment. Increasing evidence highlights the considerable and thus far underestimated role of the microenvironment in CLL pathogenesis and stresses the therapeutic value of disrupting these interactions. It is therefore essential to understand which molecular mechanisms regulate CLL trafficking between blood and lymphoid organs and how these signals are regulated during CLL cell proliferation (see Figure 1).

+ Interactions of CLL cells with the tumor microenvironment.

Characterization of CLL cell-microenvironment interactions with respect to adhesion molecules (integrins, CD44) and chemokine receptors is one of our group’s main aims. These molecules mediate lymphocyte/leukocyte extravasation from the blood vessel as well as interstitial motility within the microenvironment to localize at the appropriate site for proliferation and survival. Therapeutical interference with (malignant) cell localization may suppress minimal residual disease after chemotherapy and the development of chemoresistance. We aim to functionally identify chemokine-, integrin-, and CD44-mediated interactions of healthy and malignant lymphocytes using videomicroscopy and other microscopical approaches (Figure 2).

Because cell migration and extravasation require the physical stimulus of an applied laminar flux, we use shear flow chambers, simulating the blood flow (see Figure 3 and Movie) combined with motility experiments (under shear free conditions). Furthermore we investigate the signal transduction pathways underlying the abnormalities in CLL migration, like the dysregulations of intracellular molecules including Integrin-linked Kinase (ILK) und Rho GTPases.

+ The in vitro flow chamber apparatus and attached digital videomicroscopy setup used in the lab for recording real time and time lapse interactions of leukemic cells with their microenvironment.

2018

Correction to: Fludarabine and rituximab with escalating doses of lenalidomide followed by lenalidomide/rituximab maintenance in previously untreated chronic lymphocytic leukaemia (CLL): the REVLIRIT CLL-5 AGMT phase I/II study.

Egle, A, Steurer, M, Melchardt, T, Weiss, L, Gassner, FJ, Zaborsky, N, Geisberger, R, Catakovic, K, Hartmann, TN, Pleyer, L, Voskova, D, Thaler, J, Lang, A, Girschikofsky, M, Petzer, A, Greil, R.
Ann Hematol. 2018.

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Remission maintenance treatment options in chronic lymphocytic leukemia.

Egle, A, Pleyer, L, Melchardt, T, Hartmann, TN, Greil, R.
Cancer Treat Rev. 2018, 70:5-66.

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Fludarabine and rituximab with escalating doses of lenalidomide followed by lenalidomide/rituximab maintenance in previously untreated chronic lymphocytic leukaemia (CLL): the REVLIRIT CLL-5 AGMT phase I/II study.

Egle, A, Steurer, M, Melchardt, T, Weiss, L, Gassner, FJ, Zaborsky, N, Geisberger, R, Catakovic, K, Hartman, TN, Pleyer, L, Voskova, D, Thaler, J, Lang, A, Girschikofsky, M, Petzer, A, Greil, R.
Ann Hematol. 2018.

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Clonal evolution and heterogeneity in metastatic head and neck cancer-An analysis of the Austrian Study Group of Medical Tumour Therapy study group.

Melchardt, T, Magnes, T, Hufnagl, C, Thorner, AR, Ducar, M, Neureiter, D, Tränkenschuh, W, Klieser, E, Gaggl, A, Rösch, S, Rasp, G, Hartmann, TN, Pleyer, L, Rinnerthaler, G, Weiss, L, Greil, R, Egle, A.
Eur J Cancer. 2018, 93:69-78.

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Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia.

Gutjahr, JC, Szenes, E, Tschech, L, Asslaber, D, Schlederer, M, Roos, S, Yu, X, Girbl, T, Sternberg, C, Egle, A, Aberger, F, Alon, R, Kenner, L, Greil, R, Orian-Rousseau, V, Hartmann, TN.
Blood. 2018.

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Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia.

Tissino, E, Benedetti, D, Herman, SEM, Ten Hacken, E, Ahn, IE, Chaffee, KG, Rossi, FM, Dal Bo, M, Bulian, P, Bomben, R, Bayer, E, Härzschel, A, Gutjahr, JC, Postorino, M, Santinelli, E, Ayed, A, Zaja, F, Chiarenza, A, Pozzato, G, Chigaev, A, Sklar, LA, Burger, JA, Ferrajoli, A, Shanafelt, TD, Wiestner, A, Del Poeta, G, Hartmann, TN, Gattei, V, Zucchetto, A.
J Exp Med. 2018.

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2017

Reactivation of dormant anti-tumor immunity – a clinical perspective of therapeutic immune checkpoint modulation.

Greil, R, Hutterer, E, Hartmann, TN, Pleyer, L.
Cell Commun Signal. 2017, 15(1): 5.

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Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling.

Aberger, F, Hutterer, E, Sternberg, C, Del Burgo, PJ, Hartmann, TN.
Cell Commun Signal. 2017, 15(1): 8.

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2016

Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones.

Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
Oncotarget. 2016, xx.

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BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia.

Haerzschel, A, Catusse, J, Hutterer, E, Paunovic, M, Zirlik, K, Eibel, H, Krenn, PW, Hartmann, TN, Burger, M.
Ann Hematol. 2016, 95(12):197-1988.

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Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

Shatirishvili, M, Burk, AS, Franz, CM, Pace, G, Kastilan, T, Breuhahn, K, Hinterseer, E, Dierich, A, Bakiri, L, Wagner, EF, Ponta, H, Hartmann, TN, Tanaka, M, Orian-Rousseau, V.
Cell Death Dis. 2016, 7(11):e2461.

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CD44: More than a mere stem cell marker.

Morath, I, Hartmann, TN, Orian-Rousseau, V.
Int J Biochem Cell Biol. 2016.

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BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia.

Haerzschel, A, Catusse, J, Hutterer, E, Paunovic, M, Zirlik, K, Eibel, H, Krenn, PW, Hartmann, TN, Burger, M.
Ann Hematol. 2016, 95(12):197-1988.

Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

Shatirishvili, M, Burk, AS, Franz, CM, Pace, G, Kastilan, T, Breuhahn, K, Hinterseer, E, Dierich, A, Bakiri, L, Wagner, EF, Ponta, H, Hartmann, TN, Tanaka, M, Orian-Rousseau, V.
Cell Death Dis. 2016, 7(11):e2461.

CD44: More than a mere stem cell marker.

Morath, I, Hartmann, TN, Orian-Rousseau, V.
Int J Biochem Cell Biol. 2016.

NCCN-IPI score-independent prognostic potential of pretreatment uric acid levels for clinical outcome of diffuse large B-cell lymphoma patients.

Benedetti, D, Tissino, E, Caldana, C, Dal Bo, M, Bomben, R, Marconi, D, Ganghammer, S, Zaja, F, Pozzato, G, Di Raimondo, F, Hartmann, TN, Del Poeta, G, VanMeter, A, Zucchetto, A, Espina, V, Liotta, L, Gattei, V.
Leukemia. 2016, 30(2): 513-517.

Developing a cancer immunogene therapy approach for Epidermolysis bullosa-associated squamous cell carcinoma.

Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
Oncotarget. 2016.

Persistent CD49d engagement in circulating CLL cells: a role for blood-borne ligands?.

Benedetti, D, Tissino, E, Caldana, C, Dal Bo, M, Bomben, R, Marconi, D, Ganghammer, S, Zaja, F, Pozzato, G, Di Raimondo, F, Hartmann, TN, Del Poeta, G, VanMeter, A, Zucchetto, A, Espina, V, Liotta, L, Gattei, V.
Leukemia. 2016, 30(2): 513-517.

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ILK Induction in Lymphoid Organs by a TNFα-NF-κB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia.

Krenn, PW, Hofbauer, SW, Pucher, S, Hutterer, E, Hinterseer, E, Denk, U, Asslaber, D, Ganghammer, S, Sternberg, C, Neureiter, D, Aberger, F, Wickström, SA, Egle, A, Greil, R, Hartmann, TN.
Cancer Res. 2016, 76(8):2186-2196.

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The AKT1 isoform plays a dominant role in the survival and chemoresistance of chronic lymphocytic leukaemia cells.

Hofbauer, SW, Krenn, PW, Piñόn Hofbauer, J, Pucher, S, Asslaber, D, Egle, A, Hartmann, TN, Greil, R.
Br J Haematol. 2016, 172(5): 815-819.

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Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors.

Ganghammer, S, Gutjahr, J, Hutterer, E, Krenn, PW, Pucher, S, Zelle-Rieser, C, Jöhrer, K, Wijtmans, M, Leurs, R, Smit, MJ, Gattei, V, Greil, R, Hartmann, TN.
Haematologica. 2016, 101(3):e99-e102.

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Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones.

Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
Oncotarget. 2016.

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2015

The Role of CD44 in the Pathophysiology of Chronic Lymphocytic Leukemia.

Gutjahr, JC, Greil, R, Hartmann, TN.
FRONT IMMUNOL. 2015, 6: 177.

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CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.

Kocher, T, Asslaber, D, Zaborsky, N, Flenady, S, Denk, U, Reinthaler, P, Ablinger, M, Geisberger, R, Bauer, JW, Seiffert, M, Hartmann, TN, Greil, R, Egle, A, Hofbauer, JP.
Leukemia. 2015, xx.

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VLA-4 and CXCR4 overexpression in bone marrow of an aleukemic B-cell acute lymphoblastic leukemia presenting with osteolytic bone lesions.

Hinterseer, E, Stiefel, O, Neureiter, D, Kandler, G, Vogt, S, Hutter, J, Strasser, G, Greil, R, Hartmann, TN, Hopfinger, G.
Leuk Lymphoma. 2015, 56(8): 2465-2467.

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CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation-dependent and -independent mechanisms.

Hutterer, E, Asslaber, D, Caldana, C, Krenn, PW, Zucchetto, A, Gattei, V, Greil, R, Hartmann, TN.
Br J Haematol. 2015, 169(2):286-289.

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Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.

Kern, D, Regl, G, Hofbauer, SW, Altenhofer, P, Achatz, G, Dlugosz, A, Schnidar, H, Greil, R, Hartmann, TN, Aberger, F.
Oncogene. 2015, 34(42): 5341-5351.

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B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia.

Zaborsky, N, Holler, C, Geisberger, R, Asslaber, D, Gassner, FJ, Egger, V, Piñón-Hofbauer, J, Kocher, T, Hartmann, TN, Greil, R, Egle, A.
Haematologica. 2015, 100(8): e307-e310.

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Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2,5) translocation.

Merkel, O, Hamacher, F, Griessl, R, Grabner, L, Schiefer, AI, Prutsch, N, Baer, C, Egger, G, Schlederer, M, Krenn, PW, Hartmann, TN, Simonitsch-Klupp, I, Plass, C, Staber, PB, Moriggl, R, Turner, SD, Greil, R, Kenner, L.
J Pathol. 2015, 236(4): 44-56.

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Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model.

Gassner FJ, Zaborsky N, Catakovic K, Rebhandl S, Huemer M, Egle A, Hartmann TN, Greil R, Geisberger R.
Br J Haematol. 2015 Aug,170(4):515-22. doi: 10.1111/bjh.13467. Epub 2015 May 4.

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CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21.

Ganghammer, S, Hutterer, E, Hinterseer, E, Brachtl, G, Asslaber, D, Krenn, PW, Girbl, T, Berghammer, P, Geisberger, R, Egle, A, Zucchetto, A, Kruschinski, A, Gattei, V, Chigaev, A, Greil, R, Hartmann, TN.
Oncotarget. 2015, 6(14): 12048-12060.

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2014

Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia.

Gassner FJ, Zaborsky N, Neureiter D, Huemer M, Melchardt T, Egle A, Rebhandl S, Catakovic K, Hartmann TN, Greil R, Geisberger R.
Haematologica. 2014 May,99(5):67-9. doi: 10.3324/haematol.2013.098459. Epub 2014 Feb 21.

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Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade.

Grössinger EM, Weiss L, Zierler S, Rebhandl S, Krenn PW, Hinterseer E, Schmölzer J, Asslaber D, Hainzl S, Neureiter D, Egle A, Piñón-Hofbauer J, Hartmann TN, Greil R, Kerschbaum HH.
Leukemia. 2014 Apr,28(4):954-8. doi: 10.1038/leu.2014.37. Epub 2014 Jan 20.

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VLA-4 and CXCR4 overexpression in bone marrow of an aleukemic B-cell acute lymphoblastic leukemia presenting with osteolytic bone lesions.

Hinterseer E, Stiefel O, Neureiter D, Kandler G, Vogt S, Hutter J, Strasser G, Greil R, Hartmann TN, Hopfinger G.
Leuk Lymphoma. 2015 Feb 9:1-3. [Epub ahead of print]

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CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation-dependent and -independent mechanisms.

Hutterer E, Asslaber D, Caldana C, Krenn PW, Zucchetto A, Gattei V, Greil R, Hartmann TN.
Br J Haematol. 2015 Apr,169(2):286-9. doi: 10.1111/bjh.13188. Epub 2014 Oct 17.

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“The CXCR4 and adhesion molecule expression of CD34+ hematopoietic cells mobilized by on-demand”” addition of plerixafor to granulocyte-colony-stimulating factor.”””

Girbl T, Lunzer V, Greil R, Namberger K, Hartmann TN.
Transfusion. 2014 Sep,54(9):2325-35. doi: 10.1111/trf.12632. Epub 2014 Mar 28.

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Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility of chronic lymphocytic leukemia cells.

Hofbauer SW, Krenn PW, Ganghammer S, Asslaber D, Pichler U, Oberascher K, Henschler R, Wallner M, Kerschbaum H, Greil R, Hartmann TN.
Blood. 2014 Apr 3,123(14):2181-8. doi: 10.1182/blood-2013-08-523563. Epub 2014 Feb 5.

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The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia.

Brachtl G, Piñón Hofbauer J, Greil R, Hartmann TN.
Ann Hematol. 2014 Mar,93(3):361-74. doi: 10.1007/s00277-013-1967-y. Epub 2013 Nov 28.

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CLL cells under flow.

Hartmann TN
Blood. 2014, 123(23):3533-3534.

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2013

Blockade of the Potassium Channel KCa3.1 inhibits proliferation in Chronic Lymphocytic Leukemia

Grossinger, EM, Weiss, L, Zierler, S, Hinterseer, E, Schmolzer, J, Asslaber, D, Hainzl, S, Egle, A, Pinon, JD, Hartmann, TN, Greil, R, Kerschbaum, HH
ONKOLOGIE. 2013, 36: 191-192.

The transcription factor IRF-4 is related to prognosis in Chronic Lymphocytic Leukemia (CLL) and involved in proliferation and survival

Asslaber, D, Hofbauer, JP, Zaborsky, N, Kocher, T, Hartmann, TN, Greil, R, Egle, A
ONKOLOGIE. 2013, 36: 222-223.

Mimicking the microenvironment in chronic lymphocytic leukaemia – where does the journey go?

Asslaber D, Grössinger EM, Girbl T, Hofbauer SW, Egle A, Weiss L, Greil R, Hartmann TN.
Br J Haematol. 2013 Mar,160(5):711-4. doi: 10.1111/bjh.12151. Epub 2012 Dec 4.

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Antiapoptotic effects of p21 regarding its subcellular localization in arsenic trioxide induced apoptosis in CLL

Sifft, E, Hofbauer, JP, Asslaber, D, Hartmann, TN, Merkel, O, Greil, R
ONKOLOGIE. 2013, 36: 222-222.

CXCR3 modulates CXCL12-mediated cellular responses in chronic lymphocytic leukemia

Ganghammer, S, Hinterseer, E, Johrer, K, Greil, R, Hartmann, TN
CYTOKINE. 2013, 63(3): 264-264.

Tiam1/Rac1 signals contribute to CLL cell proliferation and chemoresistance

Hofbauer, SW, Krenn, PW, Ganghammer, S, Asslaber, D, Pichler, U, Wallner, M, Henschler, R, Greil, R, Hartmann, TN
ONKOLOGIE. 2013, 36: 56-56.

CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCL21-induced motility.

Girbl T, Hinterseer E, Grössinger EM, Asslaber D, Oberascher K, Weiss L, Hauser-Kronberger C, Neureiter D, Kerschbaum H, Naor D, Alon R, Greil R, Hartmann TN.
Cancer Res. 2013 Jan 15,73(2):561-70. doi: 10.1158/0008-5472.CAN-12-2749. Epub 2012 Nov 1.

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CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism.

Zucchetto A, Caldana C, Benedetti D, Tissino E, Rossi FM, Hutterer E, Pozzo F, Bomben R, Dal Bo M, D’Arena G, Zaja F, Pozzato G, Di Raimondo F, Hartmann TN, Rossi D, Gaidano G, Del Poeta G, Gattei V.
Blood. 2013 Nov 7,122(19):3317-21. doi: 10.1182/blood-2013-06-507335. Epub 2013 Sep 25.

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2012

Canonical and noncanonical Hedgehog/GLI signaling in hematological malignancies.

Aberger F, Kern D, Greil R, Hartmann TN.
Vitam Horm. 2012,88:25-54. doi: 10.1016/B978-0-12-394622-5.00002-X.

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Chemokine-dependent B cell-T cell interactions in chronic lymphocytic leukemia and multiple myeloma – targets for therapeutic intervention?

Jöhrer K, Hofbauer SW, Zelle-Rieser C, Greil R, Hartmann TN.
Expert Opin Biol Ther. 2012 Apr,12(4):425-41. doi: 10.1517/14712598.2012.664128. Epub 2012 Feb 15.

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2011

Fludarabine modulates composition and function of the T cell pool in patients with chronic lymphocytic leukaemia.

Gassner FJ, Weiss L, Geisberger R, Hofbauer JP, Egle A, Hartmann TN, Greil R, Tinhofer I.
Cancer Immunol Immunother. 2011 Jan,60(1):75-85. doi: 10.1007/s00262-010-0920-3. Epub 2010 Sep 21.

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Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells.

Brachtl G, Sahakyan K, Denk U, Girbl T, Alinger B, Hofbauer SW, Neureiter D, Hofbauer JP, Egle A, Greil R, Hartmann TN.
PLoS One. 2011,6(8):e23758. doi: 10.1371/journal.pone.0023758. Epub 2011 Aug 18.

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CD44-hyaluronan interactions in the pathophysiology of chronic lymphocytic leukemia – regulation by cell activation

Girbl, T, Asslaber, D, Brachtl, G, Denk, U, Weiss, L, Naor, D, Greil, R, Hartmann, TN
ONKOLOGIE. 2011, 34: 140-140.

2010

VLA-4 and CD38 in chronic lymphocytic leukemia – more than prognostic markers?

Brechtl, G, Denk, U, Pinon-Hofbauer, JD, Greil, R, Hartmann, TN
ONKOLOGIE. 2010, 33: 201-202.

The role of the VLA-4 integrin in adhesion and survival of chronic lymphocytic leukemia (CLL) cells

Sahakyan, K, Hofbauer, S, Brachtl, G, Girbl, T, Henschler, R, Greil, R, Hartmann, TN
ONKOLOGIE. 2010, 33: 201-201.

Modifying akt signaling in B-cell chronic lymphocytic leukemia cells.

Hofbauer SW, Piñón JD, Brachtl G, Haginger L, Wang W, Jöhrer K, Tinhofer I, Hartmann TN, Greil R.
Cancer Res. 2010 Sep 15,70(18):7336-44. doi: 10.1158/0008-5472.CAN-09-4411. Epub 2010 Sep 7.

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Inhibition of GLI, but not Smoothened induces apoptosis in chronic lymphocytic leukemia cells.

Desch P, Asslaber D, Kern D, Schnidar H, Mangelberger D, Alinger B, Stoecher M, Hofbauer SW, Neureiter D, Tinhofer I, Aberger F, Hartmann TN, Greil R.
Oncogene. 2010 Sep 2,29(35):4885-95. doi: 10.1038/onc.2010.243. Epub 2010 Jul 5.

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Erforschung der Chronisch Lymphatischen Leukämie am LIMCR.

Hartmann TN.
Med.ium. 6/2010.

ÖGHO-Frühjahrstagung: Chronische Lymphatische Leukämie, Adhäsionsmoleküle als mögliche therapeutische Ziele.

Hartmann TN.
JATROS Haematologie und Onkologie. 3/2010, Seite 63-65.

CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B.

Leick M, Catusse J, Follo M, Nibbs RJ, Hartmann TN, Veelken H, Burger M.
mmunology. 2010 Apr,129(4):536-46. doi: 10.1111/j.1365-2567.2009.03209.x. Epub 2009 Dec 2.

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2009

Novel therapeutics approaches to chronic lymphocytic leukemia based on recent biological insights.

Hartmann TN, Pleyer L, Desch P, Egle A, Greil R.
Discov Med. 2009 Oct,8(42):157-64.

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Molecular and cellular mechanisms of CLL: novel therapeutic approaches.

Pleyer L, Egle A, Hartmann TN, Greil R.
Nat Rev Clin Oncol. 2009 Jul,6(7):405-18. doi: 10.1038/nrclinonc.2009.72. Epub 2009 Jun 2.

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Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow.

Hartmann TN, Grabovsky V, Wang W, Desch P, Rubenzer G, Wollner S, Binsky I, Vallon-Eberhard A, Sapoznikov A, Burger M, Shachar I, Haran M, Honczarenko M, Greil R, Alon R.
Cancer Res. 2009 Apr 1,69(7):3121-30. doi: 10.1158/0008-5472.CAN-08-4136. Epub 2009 Mar 17.

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2008

A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells.

Hartmann TN, Grabovsky V, Pasvolsky R, Shulman Z, Buss EC, Spiegel A, Nagler A, Lapidot T, Thelen M, Alon R.
J Leukoc Biol. 2008 Oct,84(4):1130-40. doi: 10.1189/jlb.0208088. Epub 2008 Jul 24.

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“Leukemia cells are strongly dependent on the lymphoid tumor microenvironment, where they receive proliferative and pro-survival signals. We are interested in how CLL cells localize adjacent to these supportive signals.”

Team

Assoc.-Prof. Dr. Tanja N. Hartmann
(Deputy Head of the LIMCR, Group leader)

Elisabeth Bayer, MSc
(Biologist)

Dr. Andrea Härzschel
(Post-Doc)

Valerie Durand-Onayli, MSc
(PhD Student)

Eva Szenes, MSc
(PhD Student)

Theresa Haslauer

(Masters Student)

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