Working group:
Murine-Lymphoma

Group leader: PD Dr. Alexander Egle

CLL is a tumor that originates from an outgrowth of immune cells in the body. Similar to normal immune cells, CLL cells are part of a complex relationship composed of other immune cells and tissues components, which is of high importance for the development and progression of the disease. The study of this interplay in patient derived cancer cells has technical limitations as it is not possible to design in vitro experiments and cell culture models that are able to simulate its full complexity. Therefore, in addition to the analysis of human CLL samples, the group develops mouse models to study lymphoma development in vivo. These murine models are used to analyze the disease in its natural surrounding including all possible interaction partners, thus resembling the complexity of the human disease in an appropriate way.

 

The transplantation model allows to test pharmacological substances and to analyze potential survival benefits:

 



+ Splenocytes of a transgenic mouse which has developed a CLL-like disease are withdrawn and injected into a healthy, non-transgenic mouse. In this transplanted mouse, a very aggressive leukemia develops, which fully resembles the disease originated in the donor mouse, but has a tumor onset of a few months only. This rapid tumor development makes it possible to test and to analyze pharmacological substances and study whether a certain therapy is able to defeat CLL in the living organisms or at least delay disease progression.

  • 2016

    Researcher of the Year 2016

    Priv. Doz. Dr. Alexander Egle
    Research Group: Egle
  • 2016

    Platin medal for scientific publications, Scientific Award PMU Salzburg, 2016

    Priv. Doz. Dr. Alexander Egle
    Research Group: Egle
  • 2015

    Platin medal for scientific publications, Scientific Award PMU Salzburg, 2015

    Priv. Doz. Dr. Alexander Egle
    Research Group: Egle
  • 2014

    Platin medal for scientific publications, Scientific Award PMU Salzburg, 2014

    Priv. Doz. Dr. Alexander Egle
    Research Group: Egle
  • 2013

    Silver medal for scientific publications, Science Award PMU Salzburg, 2013

    Priv. Doz. Dr. Alexander Egle
    Research Group: Egle
  • 2013

    Best Talk Award-ICA Symposium, Paris Lodron Universität Salzburg, 2013

    Eveline Sifft
    Research Group: Egle
  • 2013

    Best Abstract Award-ÖGHO Spring meeting, 2013

    Dr. Daniela Asslaber
    Research Group: Egle
  • 2012

    Gold medal for scientific publications, Science Award PMU Salzburg, 2012

    Dr. Alexander Egle
    Research Group: Egle
  • 2012

    Silver medal for scientific publications, Science Award PMU Salzburg, 2012

    Dr. Josefina Piñón Hofbauer
    Research Group: Egle
  • 2012

    OeGHO Young Investigator Award 2012

    Dr. Daniela Asslaber/Eva Grössinger
    Research Group: Egle
  • 2011

    Gold medal for scientific publications, Scientific Award PMU Salzburg, 2011

    Priv. Doz. Dr. Alexander Egle
    Research Group: Egle
  • 2011

    Gold medal for scientific publications, Scientific Award PMU Salzburg, 2011

    Dr. Josefina Pinon Hofbauer
    Research Group: Egle
  • 2011

    Outstanding basic research, Sanofi Award, 2011

    Dr. Josefina Pinon Hofbauer
    Research Group: Egle
  • 2010

    Outstanding basic research, Sanofi Aventis Award, 2010.

    Dr. Daniela Asslaber
    Research Group: Egle
  • 2010

    Gold medal for scientific publications, Scientific Award PMU Salzburg, 2010

    Priv. Doz. OA Dr. Alexander Egle
    Research Group: Egle
  • 2010

    Wilhelm Türk Award, Annual Meeting DGHO, ÖGHO, SGH in Berlin, 2010.

    Dr. Daniela Asslaber
    Research Group: Egle
  • 2009

    ÖGHO Spring meeting in Salzburg, 2009.

    Priv. Doz. OA Dr. Alexander Egle
    Research Group: Egle
  • 2017

    Red blood cell alloimmunization in 184 patients with myeloid neoplasms treated with azacitidine - A retrospective single center experience.

    Leisch, M, Weiss, L, Lindlbauer, N, Jungbauer, C, Egle, A, Rohde, E, Greil, R, Grabmer, C, Pleyer, L.
    Leuk Res. 2017, 59:12-19.

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  • 2017

    Prognostic score in patients with recurrent or metastatic carcinoma of the head and neck treated with cetuximab and chemotherapy.

    Magnes, T, Melchardt, T, Weiss, L, Mittermair, C, Neureiter, D, Klieser, E, Gampenrieder, S, Moser, G, Gaggl, A, Greil, R, Egle, A.
    PLoS One. 2017, 12(7):e0180995.

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  • 2017

    The influence of FCGR2A and FCGR3A polymorphisms on the survival of patients with recurrent or metastatic squamous cell head and neck cancer treated with cetuximab.

    Magnes, T, Melchardt, T, Hufnagl, C, Weiss, L, Mittermair, C, Neureiter, D, Klieser, E, Rinnerthaler, G, Roesch, S, Gaggl, A, Greil, R, Egle, A.
    Pharmacogenomics J. 2017.

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  • 2017

    Ristocetin-induced platelet aggregation for monitoring of bleeding tendency in CLL treated with ibrutinib.

    Kazianka, L, Drucker, C, Skrabs, C, Thomas, W, Melchardt, T, Struve, S, Bergmann, M, Staber, PB, Porpaczy, E, Einberger, C, Heinz, M, Hauswirth, A, Raderer, M, Pabinger, I, Thalhammer, R, Egle, A, Wendtner, CM, Follows, G, Hoermann, G, Quehenberger, P, Jilma, B, Jaeger, U.
    Leukemia. 2017, 31(5):1117-1122.

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  • 2017

    Milestones in Chronic Lymphocytic Leukemia: An exciting decade of progress-10th anniversary of memo.

    Egle, A.
    Memo. 2017, 10(1):8-12.

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  • 2017

    Influence of body mass index on survival in indolent and mantle cell lymphomas: analysis of the StiL NHL1 trial.

    Weiss, L, Melchardt, T, Egle, A, Hopfinger, G, Hackl, H, Greil, R, Barth, J, Rummel, M.
    Ann Hematol. 2017.

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  • 2017

    A phase 2 study of rituximab plus lenalidomide for mucosa-associated lymphoid tissue lymphoma.

    Kiesewetter, B, Willenbacher, E, Willenbacher, W, Egle, A, Neumeister, P, Voskova, D, Mayerhoefer, ME, Simonitsch-Klupp, I, Melchardt, T, Greil, R, Raderer, M.
    Blood. 2017, 129(3):383-385

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  • 2016

    Rituximab maintenance versus observation alone in patients with chronic lymphocytic leukaemia who respond to first-line or second-line rituximab-containing chemoimmunotherapy: final results of the AGMT CLL-8a Mabtenance randomised trial.

    Greil, R, Obrtlíková, P, Smolej, L, Kozák, T, Steurer, M, Andel, J, Burgstaller, S, Mikušková, E, Gercheva, L, Nösslinger, T, Papajík, T, Ladická, M, Girschikofsky, M, Hrubiško, M, Jäger, U, Fridrik, M, Pecherstorfer, M, Králiková, E, Burcoveanu, C, Spasov, E, Petzer, A, Mihaylov, G, Raynov, J, Oexle, H, Zabernigg, A, Flochová, E, Palášthy, S, Stehlíková, O, Doubek, M, Altenhofer, P, Pleyer, L, Melchardt, T, Klingler, A, Mayer, J, Egle, A.
    Lancet Haematol. 2016, 3(7): e317-e329.

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  • 2016

    Bcl-2 proteins in development, health, and disease of the hematopoietic system.

    Kollek, M, Müller, A, Egle, A, Erlacher, M.
    FEBS J. 2016, 283(15): 2779-2810.

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  • 2016

    Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones.

    Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
    Oncotarget. 2016, xx:

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  • 2016

    NCCN-IPI score-independent prognostic potential of pretreatment uric acid levels for clinical outcome of diffuse large B-cell lymphoma patients.

    Prochazka, KT, Melchardt, T, Posch, F, Schlick, K, Deutsch, A, Beham-Schmid, C, Weiss, L, Gary, T, Neureiter, D, Klieser, E, Greil, R, Neumeister, P, Egle, A, Pichler, M.
    Br J Cancer. 2016, xx:

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  • 2016

    Fluorouracil and Dihydropyrimidine Dehydrogenase Genotyping.

    Magnes, T, Melchardt, T, Weiss, L, Hufnagl, C, Greil, R, Egle, A.
    J Clin Oncol. 2016, 34(20): 2433-2434.

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  • 2016

    Intermittent low-dose bevacizumab in hereditary hemorrhagic telangiectasia : A case report.

    Huemer, F, Dejaco, M, Grabmer, C, Melchardt, T, Neureiter, D, Mayer, G, Egle, A, Greil, R, Weiss, L.
    Wien Klin Wochenschr. 2016,

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  • 2016

    Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality?.

    Zaborsky, N, Gassner, FJ, Asslaber, D, Reinthaler, P, Denk, U, Flenady, S, Hofbauer, JP, Danner, B, Rebhandl, S, Harrer, A, Geisberger, R, Greil, R, Egle, A.
    Oncotarget. 2016,

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  • 2016

    An international, multicenter, prospective, observational study of neutropenia in patients being treated with lenalidomide?+?dexamethasone for relapsed or relapsed/refractory multiple myeloma (RR-MM).

    Kollek, M, Müller, A, Egle, A, Erlacher, M.
    FEBS J. 2016, 283(15):2779-2810

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  • 2016

    Developing a cancer immunogene therapy approach for Epidermolysis bullosa-associated squamous cell carcinoma.

    Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
    Oncotarget. 2016,

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  • 2016

    CRISPR/Cas9-mediated gene repair in the COL7A1 gene.

    Prochazka, KT, Melchardt, T, Posch, F, Schlick, K, Deutsch, A, Beham-Schmid, C, Weiss, L, Gary, T, Neureiter, D, Klieser, E, Greil, R, Neumeister, P, Egle, A, Pichler, M.
    Br J Cancer. 2016,

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  • 2016

    Bcl-2 proteins in development, health, and disease of the hematopoietic system.

    Kollek, M, Müller, A, Egle, A, Erlacher, M.
    FEBS J. 2016, 283(15):2779-2810

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  • 2016

    CD1d expression on chronic lymphocytic leukemia B cells affects disease progression and induces T cell skewing in CD8 positive and CD4CD8 double negative T cells.

    Zaborsky, N, Gassner, FJ, Asslaber, D, Reinthaler, P, Denk, U, Flenady, S, Hofbauer, JP, Danner, B, Rebhandl, S, Harrer, A, Geisberger, R, Greil, R, Egle, A.
    Oncotarget. 2016,

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  • 2016

    Fluorouracil and Dihydropyrimidine Dehydrogenase Genotyping.

    Magnes, T, Melchardt, T, Weiss, L, Hufnagl, C, Greil, R, Egle, A.
    J Clin Oncol. 2016, 34(20):2433-2434

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  • 2016

    Depletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo.

    Hanna, BS, McClanahan, F, Yazdanparast, H, Zaborsky, N, Kalter, V, Rößner, PM, Benner, A, Dürr, C, Egle, A, Gribben, JG, Lichter, P, Seiffert, M.
    Leukemia. 2016, 30(3): 570-579.

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  • 2016

    The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma.

    Troppan, KT, Melchardt, T, Wenzl, K, Schlick, K, Deutsch, A, Bullock, MD, Reitz, D, Beham-Schmid, C, Weiss, L, Neureiter, D, Tränkenschuh, W, Greil, R, Neumeister, P, Egle, A, Pichler, M.
    J Clin Pathol. 2016, 69(4):326-330.

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  • 2016

    ILK Induction in Lymphoid Organs by a TNFα-NF-κB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia.

    Krenn, PW, Hofbauer, SW, Pucher, S, Hutterer, E, Hinterseer, E, Denk, U, Asslaber, D, Ganghammer, S, Sternberg, C, Neureiter, D, Aberger, F, Wickström, SA, Egle, A, Greil, R, Hartmann, TN.
    Cancer Res. 2016, 76(8):2186-2196.

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  • 2016

    The AKT1 isoform plays a dominant role in the survival and chemoresistance of chronic lymphocytic leukaemia cells.

    Hofbauer, SW, Krenn, PW, Piñόn Hofbauer, J, Pucher, S, Asslaber, D, Egle, A, Hartmann, TN, Greil, R.
    Br J Haematol. 2016, 172(5): 815-819.

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  • 2016

    A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study.

    "Rawstron, AC, Fazi, C, Agathangelidis, A, Villamor, N, Letestu, R, Nomdedeu, J, Palacio, C, Stehlikova, O, Kreuzer, KA, Liptrot, S, O""Brien, D, de Tute, RM, Marinov, I, Hauwel, M, Spacek, M, Dobber, J, Kater, AP, Gambell, P, Soosapilla, A, Lozanski, G, Brachtl, G, Lin, K, Boysen, J, Hanson, C, Jorgensen, JL, Stetler-Stevenson, M, Yuan, C, Broome, HE, Rassenti, L, Craig, F, Delgado, J, Moreno, C, Bosch, F, Egle, A, Doubek, M, Pospisilova, S, Mulligan, S, Westerman, D, Sanders, CM, Emerson, R, Robins, HS, Kirsch, I, Shanafelt, T, Pettitt, A.Kipps, TJ, Wierda, WG, Cymbalista, F, Hallek, M, Hillmen, P, Montserrat, E, Ghia, P."
    Leukemia. 2016, 30(4):929-936.

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  • 2016

    Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones.

    Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
    Oncotarget. 2016.

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  • 2015

    The significance of pretreatment anemia in the era of R-IPI and NCCN-IPI prognostic risk assessment tools: a dual-center study in diffuse large B-cell lymphoma patients.

    Troppan, KT, Melchardt, T, Deutsch, A, Schlick, K, Stojakovic, T, Bullock, MD, Reitz, D, Beham-Schmid, C, Weiss, L, Neureiter, D, Wenzl, K, Greil, R, Neumeister, P, Egle, A, Pichler, M.
    Eur J Haematol. 2015, 95(6): 538-544.

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  • 2015

    CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.

    Kocher, T, Asslaber, D, Zaborsky, N, Flenady, S, Denk, U, Reinthaler, P, Ablinger, M, Geisberger, R, Bauer, JW, Seiffert, M, Hartmann, TN, Greil, R, Egle, A, Hofbauer, JP.
    Leukemia. 2015, xx.

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  • 2015

    Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.

    Sochalska, M, Tuzlak, S, Egle, A, Villunger, A.
    FEBS J. 2015, 282(5): 834-849.

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  • 2015

    A modified scoring of the NCCN-IPI is more accurate in the elderly and is improved by albumin and β2 -microglobulin.

    Melchardt, T, Troppan, K, Weiss, L, Hufnagl, C, Neureiter, D, Tränkenschuh, W, Hopfinger, G, Magnes, T, Deutsch, A, Neumeister, P, Hackl, H, Greil, R, Pichler, M, Egle, A.
    Br J Haematol. 2015, 168(2):239-245.

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  • 2015

    Treatment of aggressive B-cell lymphoma in elderly patients: influence of single nucleotide polymorphisms affecting pharmacodynamics of chemotherapeutics.

    Melchardt, T, Weiss, L, Hufnagl, C, Neureiter, D, Kemmerling, R, Morre, P, Boekstegers, A, Hopfinger, G, Auberger, J, Steinkirchner, S, Pleyer, L, Greil, R, Egle, A.
    Leuk Lymphoma. 2015, 56(2):353-360.

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  • 2015

    Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b.

    Them, NC, Bagienski, K, Berg, T, Gisslinger, B, Schalling, M, Chen, D, Buxhofer-Ausch, V, Thaler, J, Schloegl, E, Gastl, GA, Wolf, D, Strecker, K, Egle, A, Melchardt, T, Burgstaller, S, Willenbacher, E, Zagrijtschuk, O, Klade, C, Greil, R, Gisslinger, H, Kralovics, R.
    Am J Hematol. 2015, 90(4): 288-294.

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  • 2015

    B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia.

    Zaborsky, N, Holler, C, Geisberger, R, Asslaber, D, Gassner, FJ, Egger, V, Piñón-Hofbauer, J, Kocher, T, Hartmann, TN, Greil, R, Egle, A.
    Haematologica. 2015, 100(8): e307-e310.

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  • 2015

    Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model.

    Gassner FJ, Zaborsky N, Catakovic K, Rebhandl S, Huemer M, Egle A, Hartmann TN, Greil R, Geisberger R.
    Br J Haematol. 2015 Aug,170(4):515-22. doi: 10.1111/bjh.13467. Epub 2015 May 4.

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  • 2015

    Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial.

    Gnant, M, Pfeiler, G, Dubsky, PC, Hubalek, M, Greil, R, Jakesz, R, Wette, V, Balic, M, Haslbauer, F, Melbinger, E, Bjelic-Radisic, V, Artner-Matuschek, S, Fitzal, F, Marth, C, Sevelda, P, Mlineritsch, B, Steger, GG, Manfreda, D, Exner, R, Egle, D, Bergh, J, Kainberger, F, Talbot, S, Warner, D, Fesl, C, Singer, CF.
    LANCET. 2015, 386(9992): 433-443.

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  • 2015

    CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21.

    Ganghammer, S, Hutterer, E, Hinterseer, E, Brachtl, G, Asslaber, D, Krenn, PW, Girbl, T, Berghammer, P, Geisberger, R, Egle, A, Zucchetto, A, Kruschinski, A, Gattei, V, Chigaev, A, Greil, R, Hartmann, TN.
    Oncotarget. 2015, 6(14): 12048-12060.

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  • 2015

    CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer.

    Melchardt, T, Hufnagl, C, Magnes, T, Weiss, L, Hutarew, G, Neureiter, D, Schlattau, A, Moser, G, Gaggl, A, Tränkenschuh, W, Greil, R, Egle, A.
    BMC Cancer. 2015, 15:725

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  • 2015

    Independent Prognostic Value of Serum Markers in Diffuse Large B-Cell Lymphoma in the Era of the NCCN-IPI.

    Melchardt, T, Troppan, K, Weiss, L, Hufnagl, C, Neureiter, D, Tränkenschuh, W, Schlick, K, Huemer, F, Deutsch, A, Neumeister, P, Greil, R, Pichler, M, Egle, A.
    J Natl Compr Canc Netw. 2015, 13(12):1501-1508

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  • 2015

    Ropeginterferon alfa-2b, a novel IFNα-2b, induces high response rates with low toxicity in patients with polycythemia vera.

    Gisslinger, H, Zagrijtschuk, O, Buxhofer-Ausch, V, Thaler, J, Schloegl, E, Gastl, GA, Wolf, D, Kralovics, R, Gisslinger, B, Strecker, K, Egle, A, Melchardt, T, Burgstaller, S, Willenbacher, E, Schalling, M, Them, NC, Kadlecova, P, Klade, C, Greil, R.
    Blood. 2015, 126(15): 1762-1769.

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  • 2015

    Anti-Hu Antibody Associated Paraneoplastic Cerebellar Degeneration in Head and Neck Cancer.

    Huemer, F, Melchardt, T, Tränkenschuh, W, Neureiter, D, Moser, G, Magnes, T, Weiss, L, Schlattau, A, Hufnagl, C, Ricken, G, Höftberger, R, Greil, R, Egle, A.
    BMC Cancer. 2015, 15:996

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  • 2014

    Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia.

    Gassner FJ, Zaborsky N, Neureiter D, Huemer M, Melchardt T, Egle A, Rebhandl S, Catakovic K, Hartmann TN, Greil R, Geisberger R.
    Haematologica. 2014 May,99(5):67-9. doi: 10.3324/haematol.2013.098459. Epub 2014 Feb 21.

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  • 2014

    Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade.

    Grössinger EM, Weiss L, Zierler S, Rebhandl S, Krenn PW, Hinterseer E, Schmölzer J, Asslaber D, Hainzl S, Neureiter D, Egle A, Piñón-Hofbauer J, Hartmann TN, Greil R, Kerschbaum HH.
    Leukemia. 2014 Apr,28(4):954-8. doi: 10.1038/leu.2014.37. Epub 2014 Jan 20.

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  • 2014

    Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b.

    Them NC, Bagienski K, Berg T, Gisslinger B, Schalling M, Chen D, Buxhofer-Ausch V, Thaler J, Schloegl E, Gastl GA, Wolf D, Strecker K, Egle A, Melchardt T, Burgstaller S, Willenbacher E, Zagrijtschuk O, Klade C, Greil R, Gisslinger H, Kralovics R.
    Am J Hematol. 2015 Apr,90(4):288-94. doi: 10.1002/ajh.23928. Epub 2015 Mar 2.

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  • 2014

    A modified scoring of the NCCN-IPI is more accurate in the elderly and is improved by albumin and β(2) -microglobulin.

    Melchardt T, Troppan K, Weiss L, Hufnagl C, Neureiter D, Tränkenschuh W, Hopfinger G, Magnes T, Deutsch A, Neumeister P, Hackl H, Greil R, Pichler M, Egle A.
    Br J Haematol. 2015 Jan,168(2):239-45. doi: 10.1111/bjh.13116. Epub 2014 Sep 19.

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  • 2014

    Kasabach-Merritt phenomenon in hepatic angiosarcoma.

    Habringer S, Boekstegers A, Weiss L, Hopfinger G, Meissnitzer T, Melchardt T, Egle A, Greil R.
    Br J Haematol. 2014 Dec,167(5):716-8. doi: 10.1111/bjh.13049. Epub 2014 Jul 24.

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  • 2014

    C-reactive protein level is a prognostic indicator for survival and improves the predictive ability of the R-IPI score in diffuse large B-cell lymphoma patients.

    Troppan KT, Schlick K, Deutsch A, Melchardt T, Egle A, Stojakovic T, Beham-Schmid C, Weiss L, Neureiter D, Wenzl K, Greil R, Neumeister P, Pichler M.
    Br J Cancer. 2014 Jul 8,111(1):55-60. doi: 10.1038/bjc.2014.277. Epub 2014 May 29.

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  • 2014

    Treatment of aggressive B-cell lymphoma in elderly patients: influence of single nucleotide polymorphisms affecting pharmacodynamics of chemotherapeutics.

    Melchardt T, Weiss L, Hufnagl C, Neureiter D, Kemmerling R, Morre P, Boekstegers A, Hopfinger G, Auberger J, Steinkirchner S, Pleyer L, Greil R, Egle A.
    Leuk Lymphoma. 2015 Feb,56(2):353-60. doi: 10.3109/10428194.2014.916798. Epub 2014 Jun 25.

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  • 2014

    Liver toxicity during temozolomide chemotherapy caused by Chinese herbs.

    Melchardt T, Magnes T, Weiss L, Grundbichler M, Strasser M, Hufnagl C, Moik M, Greil R, Egle A.
    BMC Complement Altern Med. 2014 Mar 30,14:115. doi: 10.1186/1472-6882-14-115.

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  • 2014

    Human immunodeficiency virus type 2 infections in Austria.

    Taylor N, Kern JM, Prammer W, Lang A, Haas B, Gisinger M, Zangerle R, Egle A, Greil R, Oberkofler H, Eberle J.
    Wien Klin Wochenschr. 2014 Apr,126(7-8):212-6. doi: 10.1007/s00508-013-0493-1. Epub 2014 Jan 18.

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  • 2014

    Lenalidomide in combination with vorinostat and dexamethasone for the treatment of relapsed/refractory peripheral T cell lymphoma (PTCL): report of a phase I/II trial.

    Hopfinger G, Nösslinger T, Lang A, Linkesch W, Melchardt T, Weiss L, Egle A, Greil R.
    Ann Hematol. 2014 Mar,93(3):459-62. doi: 10.1007/s00277-014-2009-0. Epub 2014 Jan 18.

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  • 2014

    Increased body mass index is associated with improved overall survival in diffuse large B-cell lymphoma.

    Weiss L, Melchardt T, Habringer S, Boekstegers A, Hufnagl C, Neureiter D, Hopfinger G, Greil R, Egle A.
    Ann Oncol. 2014 Jan,25(1):171-6. doi: 10.1093/annonc/mdt481. Epub 2013 Dec 3.

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  • 2014

    Pleural decortication of a marginal zone lymphoma.

    Melchardt T, Weiss L, Namberger K, Pretsch I, Hutter J, Rettenbacher L, Neureiter D, Troch M, Greil R, Egle A.
    Ann Hematol. 2014 Jul,93(7):1253-4. doi: 10.1007/s00277-013-1960-5. Epub 2013 Nov 22.

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  • 2014

    "Old and new news in CLL: ""It""s the pathway, stupid!""."

    Egle, A,
    Blood. 2014 Aug 14,124(7):989-90. doi: 10.1182/blood-2014-05-574145.

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  • 2014

    How does lenalidomide target the chronic lymphocytic leukemia microenvironment?

    Kater, AP, Tonino, SH, Egle, A, Ramsay, AG,
    Blood. 2014 Oct 2,124(14):2184-9. doi: 10.1182/blood-2014-05-578286. Epub 2014 Aug 26.

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  • 2013

    Lenalidomide/Rituximab Maintenance After Induction With Fludarabine/Rituximab In Combination With Escalating Doses Of Lenalidomide In Previously Untreated Chronic Lymphocytic Leukemia (CLL): The Revlirit CLL5 AGMT Phase I/II Study, Final Results

    Vornamen sind ausgeschrieben-ändern? Alexander Egle, Michael Steurer, Franz Josef Gassner, Roland Geisberger, Thomas Melchardt, Lisa Pleyer, Lukas Weiss, Michael A. Fridrik, Josef Thaler, Alois Lang, Richard Greil,
    Blood (ASH Annual Meeting Abstracts). 2013. #4164:

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  • 2013

    Blockade of the Potassium Channel KCa3.1 inhibits proliferation in Chronic Lymphocytic Leukemia

    Grossinger, EM, Weiss, L, Zierler, S, Hinterseer, E, Schmolzer, J, Asslaber, D, Hainzl, S, Egle, A, Pinon, JD, Hartmann, TN, Greil, R, Kerschbaum, HH
    ONKOLOGIE. 2013, 36: 191-192.

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  • 2013

    The transcription factor IRF-4 is related to prognosis in Chronic Lymphocytic Leukemia (CLL) and involved in proliferation and survival

    Asslaber, D, Hofbauer, JP, Zaborsky, N, Kocher, T, Hartmann, TN, Greil, R, Egle, A
    ONKOLOGIE. 2013, 36: 222-223.

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  • 2013

    Mimicking the microenvironment in chronic lymphocytic leukaemia - where does the journey go?

    Asslaber D, Grössinger EM, Girbl T, Hofbauer SW, Egle A, Weiss L, Greil R, Hartmann TN.
    Br J Haematol. 2013 Mar,160(5):711-4. doi: 10.1111/bjh.12151. Epub 2012 Dec 4.

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  • 2013

    Complications of 5-azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome.

    Melchardt T, Weiss L, Pleyer L, Steinkirchner S, Auberger J, Hopfinger G, Greil R, Egle A.
    Oncol Lett. 2013 Dec,6(6):1756-1758. Epub 2013 Oct 15.

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  • 2013

    Cobas ampliprep/cobas TaqMan HIV-1 v2.0 assay: consequences at the cohort level.

    Taylor N, Grabmeier-Pfistershammer K, Egle A, Greil R, Rieger A, Ledergerber B, Oberkofler H.
    PLoS One. 2013 Aug 30,8(8):e74024. doi: 10.1371/journal.pone.0074024. eCollection 2013.

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  • 2013

    Azacitidine in patients with WHO-defined AML - results of 155 patients from the Austrian Azacitidine Registry of the AGMT-Study Group.

    Pleyer L, Stauder R, Burgstaller S, Schreder M, Tinchon C, Pfeilstocker M, Steinkirchner S, Melchardt T, Mitrovic M, Girschikofsky M, Lang A, Krippl P, Sliwa T, Egle A, Linkesch W, Voskova D, Angermann H, Greil R.
    J Hematol Oncol. 2013 Apr 29,6:32. doi: 10.1186/1756-8722-6-32.

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  • 2013

    Use of romiplostim allows for hepatitis C therapy in a HIV/HCV coinfected patient.

    Taylor N, Melchardt T, Grundbichler M, Strasser M, Egle A, Greil R.
    Ann Hematol. 2013 Jul,92(7):1001-2. doi: 10.1007/s00277-012-1659-z. Epub 2012 Dec 28.

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  • 2013

    Viral infections and their management in patients with chronic lymphocytic leukemia.

    Melchardt T, Weiss L, Greil R, Egle A.
    Leuk Lymphoma. 2013 Aug,54(8):1602-13. doi: 10.3109/10428194.2012.755178. Epub 2013 Jan 3.

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  • 2013

    What’s new in Hodgkin’s lymphoma: ASH 2012 and more

    Melchardt, T, Weiss, L, Greil, R, Egle, A,
    Magazine of European Medical Oncology. 2013, Volume 6, Issue 3: 193-196.

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  • 2013

    Influence of Body Mass Index on survival in indolent and Mantle-cell Lymphomas: Analysis of the StiL1 trial

    Weiss, L, Melchardt, T, Egle, A, Hopfinger, G, Greil, R, Barth, J, Rummel, M
    ONKOLOGIE. 2013, 36: 31-32.

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  • 2013

    [Autoimmune hemolysis accompanied by thrombopenia: consumption or myelodysplasia?].

    Melchardt, T, Weiss, L, Egle, A,
    Dtsch Med Wochenschr. 2013 Oct,138(41):2093-5. doi: 10.1055/s-0033-1349586. Epub 2013 Oct 1.

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  • 2013

    Bid-ding for mercy: twisted killer in action.

    Egle A, Asslaber D, Villunger A, Pinon-Hofbauer J.
    Cell Death and Differentiation. 2013 Jul,20(7):847-9. doi: 10.1038/cdd.2013.40.

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  • 2013

    p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa.

    Valente LJ, Gray DH, Michalak EM, Pinon-Hofbauer J, Egle A, Scott CL, Janic A, Strasser A.
    Cell Rep. 2013 May 30,3(5):1339-45. doi: 10.1016/j.celrep.2013.04.012. Epub 2013 May 9.

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  • 2013

    Protein Kinase C-?-Dependent Activation of NF-?B in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo.

    Lutzny G, Kocher T, Schmidt-Supprian M, Rudelius M, Klein-Hitpass L, Finch AJ, Dürig J, Wagner M, Haferlach C, Kohlmann A, Schnittger S, Seifert M, Wanninger S, Zaborsky N, Oostendorp R, Ruland J, Leitges M, Kuhnt T, Schäfer Y, Lampl B, Peschel C, Egle A, Ringshausen I.
    Cancer Cell. 2013 Jan 14,23(1):77-92. doi: 10.1016/j.ccr.2012.12.003.

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  • 2012

    Lysine residue at position 22 of the AID protein regulates its class switch activity.

    Geisberger R, Huemer M, Gassner FJ, Zaborsky N, Egle A, Greil R.
    PLoS One. 2012,7(2):e30667. doi: 10.1371/journal.pone.0030667. Epub 2012 Feb 20.

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  • 2012

    Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.

    Merkel O, Wacht N, Sifft E, Melchardt T, Hamacher F, Kocher T, Denk U, Hofbauer JP, Egle A, Scheideler M, Schlederer M, Steurer M, Kenner L, Greil R.
    Leukemia. 2012 Dec,26(12):2508-16. doi: 10.1038/leu.2012.147. Epub 2012 Jun 1.

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  • 2012

    Treatment of Aggressive B-Cell Lymphoma in the Elderly: The Influence of SNPs Affecting Pharmacodynamics Is Different Compared to Younger Patient

    Thomas Melchardt, Lukas Weiss, Clemens Hufnagl, Daniel Neureiter, Ralf Kemmerling, Patrick Morre, Ann Boekstegers, Georg Hopfinger, Richard Greil, Alexander Egle,
    Blood (ASH Annual Meeting Abstracts) 2012. 2012. #1613:

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  • 2012

    Feasibility of anthracycline based treatment in unselected elderly DLBCL patients

    Melchardt, T, Weiss, L, Hufnagl, C, Neureiter, D, Kemmerling, R, Hopfinger, G, Greil, R, Egle, A
    ONKOLOGIE. 2012, 35: 86-87.

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  • 2012

    Complications of 5-azacytidine: Three cases of severe colitis in a single center cohort

    Melchardt, T, Weiss, L, Pleyer, L, Steinkirchner, S, Greil, R, Egle, A
    ONKOLOGIE. 2012, 35: 149-149.

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  • 2012

    Treatment of Aggressive B-Cell Lymphoma in the Elderly: The Influence of SNPs Affecting Pharmacodynamics Is Different Compared to Younger Patient

    Melchardt, T, Weiss, L, Hufnagl, C, Neureiter, D, Kemmerling, R, Morre, P, Boekstegers, A, Hopfinger, G, Greil, R, Egle, A
    BLOOD. 2012, 120(21):

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  • 2012

    AOP2014, a Novel Peg-Proline-Interferon Alpha-2b with Improved Pharmacokinetic Properties, Is Safe and Well Tolerated and Shows Promising Efficacy in Patients with Polycythemia Vera (PV)

    Gisslinger, H, Kralovics, R, Gisslinger, B, Lechner, D, Buxhofer-Ausch, V, Strecker, K, Gastl, G, Willenbacher, E, Greil, R, Egle, A, Melchardt, T, Burgstaller, S, Schloegl, E, Tarmann, FJ, Zoerer, M, Klade, C, Zahriychuk, O, Thaler, J
    BLOOD. 2012, 120(21):

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  • 2012

    Upgraded Cobas TaqMan version 2: hidden consequences at cohort level

    Taylor, N, Grabmeier-Pfistershammer, K, Oberkofler, H, Egle, A, Rieger, A, Ledergerber, B
    J INT AIDS SOC. 2012, 15: 109-109.

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  • 2011

    Fludarabine modulates composition and function of the T cell pool in patients with chronic lymphocytic leukaemia.

    Gassner FJ, Weiss L, Geisberger R, Hofbauer JP, Egle A, Hartmann TN, Greil R, Tinhofer I.
    Cancer Immunol Immunother. 2011 Jan,60(1):75-85. doi: 10.1007/s00262-010-0920-3. Epub 2010 Sep 21.

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  • 2011

    A Combination of Fludarabine/Rituximab with Escalating Doses of Lenalidomide in Previously Untreated Chronic Lymphocytic Leukemia (CLL): The REVLIRIT CLL5 AGMT Phase I/II Study, Clinical and Exploratory Analyses of Induction Results

    Egle, A, Steurer, M, Gassner, F, Geisberger, R, Melchardt, T, Weiss, L, Fridrik, MA, Thaler, J, Lang, A, Greil, R
    BLOOD. 2011, 118(21): 135-136.

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  • 2011

    Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells.

    Brachtl G, Sahakyan K, Denk U, Girbl T, Alinger B, Hofbauer SW, Neureiter D, Hofbauer JP, Egle A, Greil R, Hartmann TN.
    PLoS One. 2011,6(8):e23758. doi: 10.1371/journal.pone.0023758. Epub 2011 Aug 18.

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  • 2011

    Complete remission of Waldenström macroglobulinemia with azacitidine and rituximab.

    Weiss L, Melchardt T, Neureiter D, Kemmerling R, Moshir S, Pleyer L, Greil R, Egle A.
    J Clin Oncol. 2011 Aug 20,29(24):e696-8. doi: 10.1200/JCO.2011.35.8283. Epub 2011 Jul 5.

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  • 2011

    Raltegravir in pregnancy: a case series presentation.

    Taylor N, Touzeau V, Geit M, Gisinger M, Egle A, Greil R, Rieger A, Zangerle R.
    Int J STD AIDS. 2011 Jun,22(6):358-60. doi: 10.1258/ijsa.2011.010469.

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  • 2011

    Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL.

    Hofbauer JP, Heyder C, Denk U, Kocher T, Holler C, Trapin D, Asslaber D, Tinhofer I, Greil R, Egle A.
    Leukemia. 2011 Sep,25(9):1452-8. doi: 10.1038/leu.2011.111. Epub 2011 May 24.

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  • 2011

    Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia.

    Weiss L, Melchardt T, Egle A, Grabmer C, Greil R, Tinhofer I.
    Cancer. 2011 May 15,117(10):2163-9. doi: 10.1002/cncr.25752. Epub 2010 Nov 18.

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  • 2011

    Treatment of invasive aspergillosis in cancer patients.

    Auberger, J, Russ, G, Greil, R, Egle, A,
    memo - Magazine of European Medical Oncology. 2011, 4 (4): 266-272.

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  • 2011

    Activity of Azacitidine in 26 Unselected, Consecutive CMML Patients Included in the Austrian Azacitidine Registry (AAR) of the AGMT-Study Group

    Pleyer, L, Stauder, R, Burgstaller, S, Schreder, M, Tinchon, C, Pfeilstocker, M, Steinkirchner, S, Melchardt, T, Mitrovic, M, Girschikofsky, M, Lang, A, Krippl, P, Egle, A, Sliwa, T, Linkesch, W, Fridrik, MA, Greil, R
    BLOOD. 2011, 118(21): 747-747.

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  • 2011

    Open-Label, Prospective, Multicentre, Phase I/II Study of AOP2014, a Novel PEG-Proline-Interferon Alpha-2b in Patients with Polycythemia Vera: Update from an Ongoing Study

    Gisslinger, H, Kralovics, R, Schoder, R, Gisslinger, B, Buxhofer-Ausch, V, Strecker, K, Wolf, D, Willenbacher, E, Greil, R, Egle, A, Melchardt, T, Burgstaller, S, Tarmann, FJ, Wachter, C, Zahriycick, O, Thaler, J
    BLOOD. 2011, 118(21): 762-762.

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  • 2011

    Tumor load reduction and prolongation of overall-survival by actinomycin D in a murine model of high-risk chronic lymphocytic leukemia

    Wacht, N, Sifft, E, Melchardt, T, Hamacher, F, Denk, U, Pinon-Hofbauer, J, Egle, A, Kocher, T, Steurer, M, Greil, R, Merkel, O
    ONKOLOGIE. 2011, 34: 141-141.

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  • 2011

    CLL CELLS INDUCE CLONAL T CELL SKEWING AND SUBSETSHIFTING IN THE MURINE TCL1 TRANSGENIC CHRONIC LYMPHOCYTIC LEUKEMIA MODEL

    Egle, A, Pinon-Hofbauer, J, Heyder, C, Denk, U, Kocher, T, Holler, C, Trapin, D, Asslaber, D, Tinhofer, I, Greil, R
    ANN ONCOL. 2011, 22: 144-144.

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  • 2011

    Clonal Diversity of the T Cell Repertoire Predicts Disease Progression in Chronic Lymphocytic Leukaemia

    Holler, C, Zaborsky, N, Hofbauer, JP, Kocher, T, Trapin, D, Asslaber, D, Greil, R, Egle, A
    BLOOD. 2011, 118(21): 365-365.

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  • 2011

    Clinical aspects of 2009 pandemic influenza A (H1N1) virus infection in Austria.

    Poeppl, W, Hell, M, Herkner, H, Stoiser, B, Fritsche, G, Schurz-Bamieh, N, Poeppl, G, Gattringer, R, Jones, N, Maass, M, Egle, A, Burgmann, H,
    Infection. 2011 Aug,39(4):341-52. doi: 10.1007/s15010-011-0121-9. Epub 2011 May 5.

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  • 2010

    MicroRNAs as biomarkers for the diagnosis and prognosis of human cancer.

    Asslaber D, Pinon Hofbauer J, Greil R, Egle A.
    Journal of Nucleic Acids Investigations. 2010, Dec 1, 1(1): 76-80.

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  • 2010

    An uncommon cause of anaemia: Sheehan's syndrome.

    Melchardt T, Namberger K, Weiss L, Egle A, Faber V, Greil R.
    Wien Klin Wochenschr. 2010 Dec,122(23-24):717-9. doi: 10.1007/s00508-010-1480-4. Epub 2010 Dec 7.

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  • 2010

    Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia.

    Merkel O, Asslaber D, Piñón JD, Egle A, Greil R.
    Cell Cycle. 2010 Jul 15,9(14):2764-8. Epub 2010 Jul 3.

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  • 2010

    microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia.

    Asslaber D, Piñón JD, Seyfried I, Desch P, Stöcher M, Tinhofer I, Egle A, Merkel O, Greil R.
    Blood. 2010 May 27,115(21):4191-7. doi: 10.1182/blood-2009-07-234823. Epub 2010 Jan 20.

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  • 2010

    Enzastaurin kills human CLL cells regardless of clinical risk profile, but fails to prolong life in a murine CLL model

    Kocher, T, Pinon, HJ, Holler, C, Denk, U, Greil, R, Egle, A
    ONKOLOGIE. 2010, 33: 40-40.

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  • 2010

    Final Analysis of Induction Treatment with Fludarabine, Cyclophosphamide Plus Rituximab (FCR) Followed by Fludarabine Plus Rituximab (FR) and Remission Maintenance Therapy with Rituximab In Previously Untreated B-Chronic Lymphocytic Leukemia (B-CLL): The Chairos AGMT CLL4/Roche ML18434 Study

    Egle, A, Weiss, L, Melchardt, T, Gunsilius, E, Petzer, AL, Fridrik, M, Lang, A, Krieger, O, Thaler, J, Greil, R
    BLOOD. 2010, 116(21): 593-594.

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  • 2010

    Deletion of Puma and p21(Waf1) In Mice Deactivates p53-Induced Cell Death and Cell Cycle Arrest, but Protects Mice From Irradiation-Induced Lymphomagenesis by a Mechanism Involving Hemopoietic Stem Cell Quiescence

    Hofbauer, JP, Holler, C, Denk, U, Asslaber, D, Fastner, G, Labi, V, Villunger, A, Greil, R, Egle, A
    BLOOD. 2010, 116(21): 45-46.

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  • 2010

    Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation.

    Labi V, Erlacher M, Krumschnabel G, Manzl C, Tzankov A, Pinon J, Egle A, Villunger A.
    Genes Dev. 2010 Aug 1,24(15):1602-7. doi: 10.1101/gad.1940210.

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  • 2010

    Riding the 2-edged sword.

    Egle A.
    Blood. 2010 Jun 3,115(22):4325-6. doi: 10.1182/blood-2010-03-272211.

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  • 2009

    Novel therapeutics approaches to chronic lymphocytic leukemia based on recent biological insights.

    Hartmann TN, Pleyer L, Desch P, Egle A, Greil R.
    Discov Med. 2009 Oct,8(42):157-64.

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  • 2009

    Molecular and cellular mechanisms of CLL: novel therapeutic approaches.

    Pleyer L, Egle A, Hartmann TN, Greil R.
    Nat Rev Clin Oncol. 2009 Jul,6(7):405-18. doi: 10.1038/nrclinonc.2009.72. Epub 2009 Jun 2.

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  • 2009

    Initial evaluation of the Roche COBAS TaqMan HIV-1 v2.0 assay for determining viral load in HIV-infected individuals.

    Taylor N, Schmid I, Egle A, Greil R, Patsch W, Oberkofler H.
    Antivir Ther. 2009,14(8):1189-93. doi: 10.3851/IMP1427.

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  • 2009

    PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia.

    Holler C, Piñón JD, Denk U, Heyder C, Hofbauer S, Greil R, Egle A.
    Blood. 2009 Mar 19,113(12):2791-4. doi: 10.1182/blood-2008-06-160713. Epub 2009 Jan 23.

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  • 2009

    The REVLIRIT CLL5 AGMT Study - a Phase I/II Trial Combining Fludarabine/Rituximab with Escalating Doses of Lenalidomide Followed by Rituximab/Lenalidomide in Untreated Chronic Lymphocytic Leukemia (CLL): Results of a Planned Interim Analysis

    Egle, A, Steurer, M, Melchardt, T, Stoll, M, Greil, R
    BLOOD. 2009, 114(22): 1341-1342.

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  • 2009

    The Inverse Correlation of Regulatory T Cells and Time to Initial Treatment in Chronic Lymphocytic B-Cell Leukemia

    Weiss, L, Melchardt, T, Grabmer, C, Egle, A, Tinhofer, I, Greil, R
    BLOOD. 2009, 114(22): 510-510.

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  • 2009

    FINAL RESULTS OF ORAL FLUDARABINE WITH CONCOMITANT SUBCUTANEOUS ALEMTUZUMAB IN RELAPSED/REFRACTORY B-CHRONIC LYMPHOCYTIC LEUKAEMIA (B-CLL): THE FLUSALEM STUDY

    Egle, A, Melchardt, T, Pleyer, L, Tinhofer, I, Lang, A, Keil, F, Thaler, J, Gunsilius, E, Fridrik, M, Greil, R
    HAEMATOL-HEMATOL J. 2009, 94: 140-140.

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  • 2008

    Minimal Residual Disease (MRD) and T/NK Cell Dynamics during Fludarabine, Cyclophosphamide Plus Rituximab (FCR) Followed by Fludarabine Plus Rituximab (FR) and Remission Maintenance Therapy with Rituximab in Previously Untreated B-Chronic Lymphocytic Leukemia (B-CLL): Riskfactor Stratification in the Chairos Study.

    Egle, A, Weiss, L, Gassner, F, Russ, G, Pleyer, L, Gunsilius, E, Tinhofer, I, Thaler, J, Petzer, AL, Greil, R
    BLOOD. 2008, 112(11): 1089-1089.

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  • 2008

    T Cell Dynamics during the Pretumor and Tumor Phase in the Murine Tcll Transgenic Chronic Lymphocytic Leukemia Model

    Egle, A, Pinon, JD, Heyder, C, Holler, C, Denk, U, Tinhofer, I, Greil, R
    BLOOD. 2008, 112(11): 1078-1078.

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  • 2008

    Bim and Bmf in tissue homeostasis and malignant disease.

    Piñon JD, Labi V, Egle A, Villunger A.
    Oncogene. 2008 Dec,27 Suppl 1:S41-52. doi: 10.1038/onc.2009.42.

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  • 2007

    Planned first efficacy and safety analysis of de-intensified induction with fludarabine, cyclophosphamide plus rituximab (FCR) followed by fludarabine plus rituximab (FR) and remission maintenance therapy with rituximab in previously untreated B-chronic lymphocytic leukemia (B-CLL): The chairos study

    Egle, A, Weiss, L, Russ, G, Thoedtmann, R, Pleyer, L, Gastl, G, Thaler, J, Petzer, A, Tinhofer, I, Greil, R
    BLOOD. 2007, 110(11): 609A-609A.

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  • 2006

    The effect of IgVH mutational status on the induction of apoptosis by rituximab in patients with heavily pretreated B-cell chronic lymphocytic leukemia: evidence from a clinical phase I/II trial.

    Tinhofer I, Steurer M, Leitinger G, Rumpold H, Egle A, Erdel M, Greil R.
    Haematologica. 2006 Sep,91(9):1291-3.

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  • 2006

    Expression levels of CD38 in T cells predict course of disease in male patients with B-chronic lymphocytic leukemia.

    Tinhofer I, Rubenzer G, Holler C, Hofstaetter E, Stoecher M, Egle A, Steurer M, Greil R.
    Blood. 2006 Nov 1,108(9):2950-6. Epub 2006 Jul 6.

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  • 2006

    Planned first safety and efficacy analysis of oral fludarabine combined with subcutaneous alemtuzumab in 2(nd) line therapy of B-chronic lymphocytic leukaemia (B-CLL): The FLUSALEM study.

    Egle, A, Tinhofer, I, Russ, G, Rass, C, Greil, R
    BLOOD. 2006, 108(11): 336B-336B.

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  • 2005

    Expression levels of CD38 in tumor cells and T-cells are of prognostic value in B-CLL

    Tinhofer, I, Rubenzer, G, Egle, A, Greil, R
    BLOOD. 2005, 106(11): 347A-347A.

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  • 2001

    Stepping up treatment with Rituxan (R) (rituximab, Mabthera (R)) for CLL patients with advanced stage of disease relapsing after or refractory to conventional chemotherapy.

    Greil, R, Steurer, M, Egle, A, Stauder, R, Anether, G, Ulmer, L, Tinhofer, I, Gastl, G
    BLOOD. 2001, 98(11): 289B-290B.

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  • 2000

    Analysis of Bcl-2 protein expression in chronic lymphocytic leukemia. A comparison of three semiquantitation techniques.

    Marschitz I, Tinhofer I, Hittmair A, Egle A, Kos M, Greil R.
    Am J Clin Pathol. 2000 Feb,113(2):219-29.

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  • 2000

    Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma.

    Tinhofer I, Marschitz I, Henn T, Egle A, Greil R.
    Blood. 2000 Jan 15,95(2):610-8.

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  • 1998

    On the role and significance of Fas (Apo-1/CD95) ligand (FasL) expression in immune privileged tissues and cancer cells using multiple myeloma as a model.

    Greil R, Egle A, Villunger A.
    Leuk Lymphoma. 1998 Nov,31(5-6):477-90.

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  • 1998

    Functional granulocyte/macrophage colony stimulating factor receptor is constitutively expressed on neoplastic plasma cells and mediates tumour cell longevity.

    Villunger A, Egle A, Kos M, Egle D, Tinhofer I, Henn T, Uberall F, Maly K, Greil R.
    Br J Haematol. 1998 Sep,102(4):1069-80.

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  • 1998

    Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia.

    Tinhofer I, Marschitz I, Kos M, Henn T, Egle A, Villunger A, Greil R.
    Blood. 1998 Jun 1,91(11):4273-81.

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  • 1998

    Inversion of CD4(+)/CD8(+) ratio in B chronic lymphocytic leukemia correlates with differential sensitivity of CD4(+) and CD8(+) T lymphocytes to the killing efficacy of Fas (APO-1/CD95) ligand(+) tumor cells.

    Tinhofer, I, Marschitz, I, Kos, M, Henn, T, Egle, A, Villunger, A, Greil, R
    BLOOD. 1998, 92(10): 271B-271B.

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  • 1997

    Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells.

    Villunger A, Egle A, Kos M, Hartmann BL, Geley S, Kofler R, Greil R.
    Cancer Res. 1997 Aug 15,57(16):3331-4.

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  • 1997

    The interleukin 1beta-converting enzyme inhibitor CrmA prevents Apo1/Fas- but not glucocorticoid-induced poly(ADP-ribose) polymerase cleavage and apoptosis in lymphoblastic leukemia cells.

    Geley S, Hartmann BL, Kapelari K, Egle A, Villunger A, Heidacher D, Greil R, Auer B, Kofler R.
    FEBS Lett. 1997 Jan 27,402(1):36-40.

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  • 1997

    Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance.

    Villunger A, Egle A, Marschitz I, Kos M, Böck G, Ludwig H, Geley S, Kofler R, Greil R.
    Blood. 1997 Jul 1,90(1):12-20.

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  • 1997

    Expression of Apo-1/Fas (CD95), Bcl-2 Bax and Bcl-x in myeloma cell lines: relationship between responsiveness to anti-Fas mab and p53 functional status.

    Egle A, Villunger A, Marschitz I, Kos M, Hittmair A, Lukas P, Grünewald K, Greil R.
    Br J Haematol. 1997 May,97(2):418-28.

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  • 1997

    Fas (Apo-1/CD95) - Ligand expression on neoplastic plasma cells and its role for the expansion of the neoplastic clone.

    Greil, R, Villunger, A, Egle, A, Marschitz, L, Kos, M, Bock, G, Ludwig, H, Geley, S, Kofler, R
    BLOOD. 1997, 90(10): 1578-1578.

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  • 1996

    Modulation of Apo-1/Fas (CD95)-induced programmed cell death in myeloma cells by interferon-alpha 2.

    Egle A, Villunger A, Kos M, Böck G, Gruber J, Auer B, Greil R.
    Eur J Immunol. 1996 Dec,26(12):3119-26.

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  • 1996

    IL-10 serum levels in B-cell chronic lymphocytic leukaemia.

    Egle A, Marschitz I, Posch B, Herold M, Greil R.
    Br J Haematol. 1996 Jul,94(1):211-2.

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  • 1996

    2',2'-Difluorodeoxycytidine (gemcitabine) induces apoptosis in myeloma cell lines resistant to steroids and 2-chlorodeoxyadenosine (2-CdA).

    Gruber J, Geisen F, Sgonc R, Egle A, Villunger A, Boeck G, Konwalinka G, Greil R.
    Stem Cells. 1996 May,14(3):351-62.

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  • 1996

    Constituents of autocrine IL-6 loops in myeloma cell lines and their targeting for suppression of neoplastic growth by antibody strategies.

    Villunger A, Egle A, Kos M, Hittmair A, Maly K, Greil R.
    Int J Cancer. 1996 Feb 8,65(4):498-505.

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  • 1995

    Recombinant human erythropoietin in the anemia associated with multiple myeloma or non-Hodgkin's lymphoma: dose finding and identification of predictors of response.

    Cazzola M, Messinger D, Battistel V, Bron D, Cimino R, Enller-Ziegler L, Essers U, Greil R, Grossi A, Jäger G, LeMevel A, Najman A, Silingardi V, Spriano M, van Hoof A, Ehmer B.
    Blood. 1995 Dec 15,86(12):4446-53.

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“The complexity of the disease can be mimicked in the murine model. In this system we are analyzing the effect of novel therapy concepts and the communication of leukemic cells with the immune system.”

Team:

 

Former staff:

Dr. Piñón Hofbauer Josefina

Dr. Kocher Thomas

Dr. Holler Claudia

Sifft Eveline, MSc