Working Group:
CLL Cell Trafficking and
Microenvironment

Group leader: Assoc.-Prof. Dr. Tanja Hartmann

Emerging evidence suggests that a crosstalk of tumor cells with surrounding immune and accessory cells markedly contributes to the pathophysiology of B cell malignancies such as chronic lymphocytic leukemia (CLL). CLL is a dynamic disease characterized by a balance of cells circulating in the peripheral blood and cells located in supportive zones of lymphoid organs. Proliferation and survival of CLL cells depend on a complex interplay of distinct cell types, the extracellular matrix, and soluble factors within the organs, collectively referred to as the CLL microenvironment. Increasing evidence highlights the considerable and thus far underestimated role of the microenvironment in CLL pathogenesis and stresses the therapeutic value of disrupting these interactions. It is therefore essential to understand which molecular mechanisms regulate CLL trafficking between blood and lymphoid organs and how these signals are regulated during CLL cell proliferation (see Figure 1).

 


+ Interactions of CLL cells with the tumor microenvironment.

 

Characterization of CLL cell-microenvironment interactions with respect to adhesion molecules (integrins, CD44) and chemokine receptors is one of our group's main aims. These molecules mediate lymphocyte/leukocyte extravasation from the blood vessel as well as interstitial motility within the microenvironment to localize at the appropriate site for proliferation and survival. Therapeutical interference with (malignant) cell localization may suppress minimal residual disease after chemotherapy and the development of chemoresistance. We aim to functionally identify chemokine-, integrin-, and CD44-mediated interactions of healthy and malignant lymphocytes using videomicroscopy and other microscopical approaches (Figure 2).

 

 

Because cell migration and extravasation require the physical stimulus of an applied laminar flux, we use shear flow chambers, simulating the blood flow (see Figure 3 and Movie) combined with motility experiments (under shear free conditions). Furthermore we investigate the signal transduction pathways underlying the abnormalities in CLL migration, like the dysregulations of intracellular molecules including Integrin-linked Kinase (ILK) und Rho GTPases.

 

 

+ The in vitro flow chamber apparatus and attached digital videomicroscopy setup used in the lab for recording real time and time lapse interactions of leukemic cells with their microenvironment.

 

 

 

 

+ Chemokine (SDF-1)-induced arrest of lymphocytes on inflamed endothelium under shear flow.

  • 2016

    Gold medal for scientific publications, Scientific Award PMU Salzburg, 2016

    Priv. Doz. Dr. Tanja Hartmann
    Research Group: Hartmann
  • 2015

    Gold medal for scientific publications, Scientific Award PMU Salzburg, 2015

    Priv. Doz. Dr. Tanja Hartmann
    Research Group: Hartmann
  • 2015

    Bronze medal for scientific publications, Scientific Award PMU Salzburg, 2015

    Peter Krenn, MSc
    Research Group: Hartmann
  • 2014

    Bronze medal for scientific publications, Scientific Award PMU Salzburg, 2014

    Priv. Doz. Dr. Tanja Hartmann
    Research Group: Hartmann
  • 2014

    Sanofi Award, 2014

    Dr. Sebastian Hofbauer
    Research Group: Hartmann
  • 2014

    Sanofi Award, 2014

    Dr. Eva Grössinger
    Research Group: Hartmann
  • 2014

    OeGHO Young Investigator Award 2014

    Elisabeth Hinterseer
    Research Group: Hartmann
  • 2014

    OeGHO Young Investigator Award 2014

    Evelyn Hutterer
    Research Group: Hartmann
  • 2013

    ASH abstract achievement travel award 2013

    Elisabeth Hinterseer
    Research Group: Hartmann
  • 2013

    Posterpreis in der Sitzung CLL auf der DGHO/OeGHOJahrestagung 2013

    Peter Krenn/Dr. Sebastian Hofbauer
    Research Group: Hartmann
  • 2013

    Wilhelm Türk Award, Annual Meeting ÖGHO, 2013

    Dr. Tamara Girbl
    Research Group: Hartmann
  • 2013

    Sanofi Award, 2013

    Dr. Tamara Girbl
    Research Group: Hartmann
  • 2013

    Gold medal for scientific publications, Science Award PMU Salzburg, 2013

    Dr. Tanja N. Hartmann
    Research Group: Hartmann
  • 2013

    Best Abstract Award-ÖGHO Spring meeting, 2013

    Frank Hamacher
    Research Group: Hartmann
  • 2012

    Bronze medal for scientific publications, Science Award PMU Salzburg, 2012

    Dr. Tanja N. Hartmann
    Research Group: Hartmann
  • 2011

    Silver medal for scientific publications, Science Award PMU Salzburg, 2011

    Dr. Sebastian Hofbauer
    Research Group: Hartmann
  • 2011

    Gold medal for scientific publications, Scientific Award PMU Salzburg, 2011

    Dr. Tanja Hartmann
    Research Group: Hartmann
  • 2011

    "Lecture Award, ""CD44-Hyaluronsäure Interaktionen in der Chronisch Lymphatischen Leukämie - Regulation durch Zellaktivierung"", Young Investigators ÖGHO Pörtschach, 2011."

    Mag. Tamara Girbl
    Research Group: Hartmann
  • 2011

    Poster Award, Category Cell adhesion, 34. Annual Meeting of the German Society for Cell Biology in Bonn, 2011.

    Mag. Tamara Girbl
    Research Group: Hartmann
  • 2010

    Best publishing scientist, PMU Salzburg, 2010.

    Dr. Tanja N. Hartmann
    Research Group: Hartmann
  • 2010

    Lecture Award, Young Investigators, ÖGHO Frühjahrstagung in Bregenz, 2010.

    Dipl. Biochemiker Frank Hamacher
    Research Group: Hartmann
  • 2010

    Poster Award, ÖGHO Spring meeting in Bregenz, 2010.

    Dr. Kara Sahaykan
    Research Group: Hartmann
  • 2009

    Poster Award ÖGHO Spring meeting in Salzburg, 2009

    Dr. Petra Desch
    Research Group: Hartmann
  • 2008

    Wolfgang Denk Award ÖGHO, 2008

    Dr. Irina Gryshchenko
    Research Group: Hartmann
  • 2017

    Reactivation of dormant anti-tumor immunity - a clinical perspective of therapeutic immune checkpoint modulation.

    Greil, R, Hutterer, E, Hartmann, TN, Pleyer, L.
    Cell Commun Signal. 2017, 15(1): 5.

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  • 2017

    Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signaling.

    Aberger, F, Hutterer, E, Sternberg, C, Del Burgo, PJ, Hartmann, TN.
    Cell Commun Signal. 2017, 15(1): 8.

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  • 2016

    Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones.

    Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
    Oncotarget. 2016, xx.

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  • 2016

    BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia.

    Haerzschel, A, Catusse, J, Hutterer, E, Paunovic, M, Zirlik, K, Eibel, H, Krenn, PW, Hartmann, TN, Burger, M.
    Ann Hematol. 2016, 95(12):197-1988.

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  • 2016

    Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

    Shatirishvili, M, Burk, AS, Franz, CM, Pace, G, Kastilan, T, Breuhahn, K, Hinterseer, E, Dierich, A, Bakiri, L, Wagner, EF, Ponta, H, Hartmann, TN, Tanaka, M, Orian-Rousseau, V.
    Cell Death Dis. 2016, 7(11):e2461.

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  • 2016

    CD44: More than a mere stem cell marker.

    Morath, I, Hartmann, TN, Orian-Rousseau, V.
    Int J Biochem Cell Biol. 2016.

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  • 2016

    BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia.

    Haerzschel, A, Catusse, J, Hutterer, E, Paunovic, M, Zirlik, K, Eibel, H, Krenn, PW, Hartmann, TN, Burger, M.
    Ann Hematol. 2016, 95(12):197-1988.

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  • 2016

    Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

    Shatirishvili, M, Burk, AS, Franz, CM, Pace, G, Kastilan, T, Breuhahn, K, Hinterseer, E, Dierich, A, Bakiri, L, Wagner, EF, Ponta, H, Hartmann, TN, Tanaka, M, Orian-Rousseau, V.
    Cell Death Dis. 2016, 7(11):e2461.

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  • 2016

    CD44: More than a mere stem cell marker.

    Morath, I, Hartmann, TN, Orian-Rousseau, V.
    Int J Biochem Cell Biol. 2016.

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  • 2016

    NCCN-IPI score-independent prognostic potential of pretreatment uric acid levels for clinical outcome of diffuse large B-cell lymphoma patients.

    Benedetti, D, Tissino, E, Caldana, C, Dal Bo, M, Bomben, R, Marconi, D, Ganghammer, S, Zaja, F, Pozzato, G, Di Raimondo, F, Hartmann, TN, Del Poeta, G, VanMeter, A, Zucchetto, A, Espina, V, Liotta, L, Gattei, V.
    Leukemia. 2016, 30(2): 513-517.

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  • 2016

    Developing a cancer immunogene therapy approach for Epidermolysis bullosa-associated squamous cell carcinoma.

    Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
    Oncotarget. 2016.

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  • 2016

    Persistent CD49d engagement in circulating CLL cells: a role for blood-borne ligands?.

    Benedetti, D, Tissino, E, Caldana, C, Dal Bo, M, Bomben, R, Marconi, D, Ganghammer, S, Zaja, F, Pozzato, G, Di Raimondo, F, Hartmann, TN, Del Poeta, G, VanMeter, A, Zucchetto, A, Espina, V, Liotta, L, Gattei, V.
    Leukemia. 2016, 30(2): 513-517.

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  • 2016

    ILK Induction in Lymphoid Organs by a TNFα-NF-κB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia.

    Krenn, PW, Hofbauer, SW, Pucher, S, Hutterer, E, Hinterseer, E, Denk, U, Asslaber, D, Ganghammer, S, Sternberg, C, Neureiter, D, Aberger, F, Wickström, SA, Egle, A, Greil, R, Hartmann, TN.
    Cancer Res. 2016, 76(8):2186-2196.

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  • 2016

    The AKT1 isoform plays a dominant role in the survival and chemoresistance of chronic lymphocytic leukaemia cells.

    Hofbauer, SW, Krenn, PW, Piñόn Hofbauer, J, Pucher, S, Asslaber, D, Egle, A, Hartmann, TN, Greil, R.
    Br J Haematol. 2016, 172(5): 815-819.

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  • 2016

    Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors.

    Ganghammer, S, Gutjahr, J, Hutterer, E, Krenn, PW, Pucher, S, Zelle-Rieser, C, Jöhrer, K, Wijtmans, M, Leurs, R, Smit, MJ, Gattei, V, Greil, R, Hartmann, TN.
    Haematologica. 2016, 101(3):e99-e102.

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  • 2016

    Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones.

    Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
    Oncotarget. 2016.

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  • 2015

    The Role of CD44 in the Pathophysiology of Chronic Lymphocytic Leukemia.

    Gutjahr, JC, Greil, R, Hartmann, TN.
    FRONT IMMUNOL. 2015, 6: 177.

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  • 2015

    CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.

    Kocher, T, Asslaber, D, Zaborsky, N, Flenady, S, Denk, U, Reinthaler, P, Ablinger, M, Geisberger, R, Bauer, JW, Seiffert, M, Hartmann, TN, Greil, R, Egle, A, Hofbauer, JP.
    Leukemia. 2015, xx.

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  • 2015

    VLA-4 and CXCR4 overexpression in bone marrow of an aleukemic B-cell acute lymphoblastic leukemia presenting with osteolytic bone lesions.

    Hinterseer, E, Stiefel, O, Neureiter, D, Kandler, G, Vogt, S, Hutter, J, Strasser, G, Greil, R, Hartmann, TN, Hopfinger, G.
    Leuk Lymphoma. 2015, 56(8): 2465-2467.

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  • 2015

    CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation-dependent and -independent mechanisms.

    Hutterer, E, Asslaber, D, Caldana, C, Krenn, PW, Zucchetto, A, Gattei, V, Greil, R, Hartmann, TN.
    Br J Haematol. 2015, 169(2):286-289.

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  • 2015

    Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.

    Kern, D, Regl, G, Hofbauer, SW, Altenhofer, P, Achatz, G, Dlugosz, A, Schnidar, H, Greil, R, Hartmann, TN, Aberger, F.
    Oncogene. 2015, 34(42): 5341-5351.

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  • 2015

    B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia.

    Zaborsky, N, Holler, C, Geisberger, R, Asslaber, D, Gassner, FJ, Egger, V, Piñón-Hofbauer, J, Kocher, T, Hartmann, TN, Greil, R, Egle, A.
    Haematologica. 2015, 100(8): e307-e310.

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  • 2015

    Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2,5) translocation.

    Merkel, O, Hamacher, F, Griessl, R, Grabner, L, Schiefer, AI, Prutsch, N, Baer, C, Egger, G, Schlederer, M, Krenn, PW, Hartmann, TN, Simonitsch-Klupp, I, Plass, C, Staber, PB, Moriggl, R, Turner, SD, Greil, R, Kenner, L.
    J Pathol. 2015, 236(4): 44-56.

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  • 2015

    Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model.

    Gassner FJ, Zaborsky N, Catakovic K, Rebhandl S, Huemer M, Egle A, Hartmann TN, Greil R, Geisberger R.
    Br J Haematol. 2015 Aug,170(4):515-22. doi: 10.1111/bjh.13467. Epub 2015 May 4.

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  • 2015

    CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21.

    Ganghammer, S, Hutterer, E, Hinterseer, E, Brachtl, G, Asslaber, D, Krenn, PW, Girbl, T, Berghammer, P, Geisberger, R, Egle, A, Zucchetto, A, Kruschinski, A, Gattei, V, Chigaev, A, Greil, R, Hartmann, TN.
    Oncotarget. 2015, 6(14): 12048-12060.

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  • 2014

    Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia.

    Gassner FJ, Zaborsky N, Neureiter D, Huemer M, Melchardt T, Egle A, Rebhandl S, Catakovic K, Hartmann TN, Greil R, Geisberger R.
    Haematologica. 2014 May,99(5):67-9. doi: 10.3324/haematol.2013.098459. Epub 2014 Feb 21.

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  • 2014

    Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade.

    Grössinger EM, Weiss L, Zierler S, Rebhandl S, Krenn PW, Hinterseer E, Schmölzer J, Asslaber D, Hainzl S, Neureiter D, Egle A, Piñón-Hofbauer J, Hartmann TN, Greil R, Kerschbaum HH.
    Leukemia. 2014 Apr,28(4):954-8. doi: 10.1038/leu.2014.37. Epub 2014 Jan 20.

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  • 2014

    VLA-4 and CXCR4 overexpression in bone marrow of an aleukemic B-cell acute lymphoblastic leukemia presenting with osteolytic bone lesions.

    Hinterseer E, Stiefel O, Neureiter D, Kandler G, Vogt S, Hutter J, Strasser G, Greil R, Hartmann TN, Hopfinger G.
    Leuk Lymphoma. 2015 Feb 9:1-3. [Epub ahead of print]

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  • 2014

    CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation-dependent and -independent mechanisms.

    Hutterer E, Asslaber D, Caldana C, Krenn PW, Zucchetto A, Gattei V, Greil R, Hartmann TN.
    Br J Haematol. 2015 Apr,169(2):286-9. doi: 10.1111/bjh.13188. Epub 2014 Oct 17.

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  • 2014

    "The CXCR4 and adhesion molecule expression of CD34+ hematopoietic cells mobilized by on-demand"" addition of plerixafor to granulocyte-colony-stimulating factor."""

    Girbl T, Lunzer V, Greil R, Namberger K, Hartmann TN.
    Transfusion. 2014 Sep,54(9):2325-35. doi: 10.1111/trf.12632. Epub 2014 Mar 28.

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  • 2014

    Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility of chronic lymphocytic leukemia cells.

    Hofbauer SW, Krenn PW, Ganghammer S, Asslaber D, Pichler U, Oberascher K, Henschler R, Wallner M, Kerschbaum H, Greil R, Hartmann TN.
    Blood. 2014 Apr 3,123(14):2181-8. doi: 10.1182/blood-2013-08-523563. Epub 2014 Feb 5.

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  • 2014

    The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia.

    Brachtl G, Piñón Hofbauer J, Greil R, Hartmann TN.
    Ann Hematol. 2014 Mar,93(3):361-74. doi: 10.1007/s00277-013-1967-y. Epub 2013 Nov 28.

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  • 2014

    CLL cells under flow.

    Hartmann TN
    Blood. 2014 Jun 5,123(23):3533-4. doi: 10.1182/blood-2014-04-565358. Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia. [Blood. 2014]

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  • 2013

    Blockade of the Potassium Channel KCa3.1 inhibits proliferation in Chronic Lymphocytic Leukemia

    Grossinger, EM, Weiss, L, Zierler, S, Hinterseer, E, Schmolzer, J, Asslaber, D, Hainzl, S, Egle, A, Pinon, JD, Hartmann, TN, Greil, R, Kerschbaum, HH
    ONKOLOGIE. 2013, 36: 191-192.

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  • 2013

    The transcription factor IRF-4 is related to prognosis in Chronic Lymphocytic Leukemia (CLL) and involved in proliferation and survival

    Asslaber, D, Hofbauer, JP, Zaborsky, N, Kocher, T, Hartmann, TN, Greil, R, Egle, A
    ONKOLOGIE. 2013, 36: 222-223.

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  • 2013

    Mimicking the microenvironment in chronic lymphocytic leukaemia - where does the journey go?

    Asslaber D, Grössinger EM, Girbl T, Hofbauer SW, Egle A, Weiss L, Greil R, Hartmann TN.
    Br J Haematol. 2013 Mar,160(5):711-4. doi: 10.1111/bjh.12151. Epub 2012 Dec 4.

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  • 2013

    Antiapoptotic effects of p21 regarding its subcellular localization in arsenic trioxide induced apoptosis in CLL

    Sifft, E, Hofbauer, JP, Asslaber, D, Hartmann, TN, Merkel, O, Greil, R
    ONKOLOGIE. 2013, 36: 222-222.

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  • 2013

    CXCR3 modulates CXCL12-mediated cellular responses in chronic lymphocytic leukemia

    Ganghammer, S, Hinterseer, E, Johrer, K, Greil, R, Hartmann, TN
    CYTOKINE. 2013, 63(3): 264-264.

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  • 2013

    Tiam1/Rac1 signals contribute to CLL cell proliferation and chemoresistance

    Hofbauer, SW, Krenn, PW, Ganghammer, S, Asslaber, D, Pichler, U, Wallner, M, Henschler, R, Greil, R, Hartmann, TN
    ONKOLOGIE. 2013, 36: 56-56.

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  • 2013

    CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCL21-induced motility.

    Girbl T, Hinterseer E, Grössinger EM, Asslaber D, Oberascher K, Weiss L, Hauser-Kronberger C, Neureiter D, Kerschbaum H, Naor D, Alon R, Greil R, Hartmann TN.
    Cancer Res. 2013 Jan 15,73(2):561-70. doi: 10.1158/0008-5472.CAN-12-2749. Epub 2012 Nov 1.

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  • 2013

    CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism.

    Zucchetto A, Caldana C, Benedetti D, Tissino E, Rossi FM, Hutterer E, Pozzo F, Bomben R, Dal Bo M, D'Arena G, Zaja F, Pozzato G, Di Raimondo F, Hartmann TN, Rossi D, Gaidano G, Del Poeta G, Gattei V.
    Blood. 2013 Nov 7,122(19):3317-21. doi: 10.1182/blood-2013-06-507335. Epub 2013 Sep 25.

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  • 2012

    Canonical and noncanonical Hedgehog/GLI signaling in hematological malignancies.

    Aberger F, Kern D, Greil R, Hartmann TN.
    Vitam Horm. 2012,88:25-54. doi: 10.1016/B978-0-12-394622-5.00002-X.

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  • 2012

    Chemokine-dependent B cell-T cell interactions in chronic lymphocytic leukemia and multiple myeloma - targets for therapeutic intervention?

    Jöhrer K, Hofbauer SW, Zelle-Rieser C, Greil R, Hartmann TN.
    Expert Opin Biol Ther. 2012 Apr,12(4):425-41. doi: 10.1517/14712598.2012.664128. Epub 2012 Feb 15.

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  • 2011

    Fludarabine modulates composition and function of the T cell pool in patients with chronic lymphocytic leukaemia.

    Gassner FJ, Weiss L, Geisberger R, Hofbauer JP, Egle A, Hartmann TN, Greil R, Tinhofer I.
    Cancer Immunol Immunother. 2011 Jan,60(1):75-85. doi: 10.1007/s00262-010-0920-3. Epub 2010 Sep 21.

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  • 2011

    Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells.

    Brachtl G, Sahakyan K, Denk U, Girbl T, Alinger B, Hofbauer SW, Neureiter D, Hofbauer JP, Egle A, Greil R, Hartmann TN.
    PLoS One. 2011,6(8):e23758. doi: 10.1371/journal.pone.0023758. Epub 2011 Aug 18.

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  • 2011

    CD44-hyaluronan interactions in the pathophysiology of chronic lymphocytic leukemia - regulation by cell activation

    Girbl, T, Asslaber, D, Brachtl, G, Denk, U, Weiss, L, Naor, D, Greil, R, Hartmann, TN
    ONKOLOGIE. 2011, 34: 140-140.

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  • 2010

    VLA-4 and CD38 in chronic lymphocytic leukemia - more than prognostic markers?

    Brechtl, G, Denk, U, Pinon-Hofbauer, JD, Greil, R, Hartmann, TN
    ONKOLOGIE. 2010, 33: 201-202.

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  • 2010

    The role of the VLA-4 integrin in adhesion and survival of chronic lymphocytic leukemia (CLL) cells

    Sahakyan, K, Hofbauer, S, Brachtl, G, Girbl, T, Henschler, R, Greil, R, Hartmann, TN
    ONKOLOGIE. 2010, 33: 201-201.

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  • 2010

    Modifying akt signaling in B-cell chronic lymphocytic leukemia cells.

    Hofbauer SW, Piñón JD, Brachtl G, Haginger L, Wang W, Jöhrer K, Tinhofer I, Hartmann TN, Greil R.
    Cancer Res. 2010 Sep 15,70(18):7336-44. doi: 10.1158/0008-5472.CAN-09-4411. Epub 2010 Sep 7.

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  • 2010

    Inhibition of GLI, but not Smoothened induces apoptosis in chronic lymphocytic leukemia cells.

    Desch P, Asslaber D, Kern D, Schnidar H, Mangelberger D, Alinger B, Stoecher M, Hofbauer SW, Neureiter D, Tinhofer I, Aberger F, Hartmann TN, Greil R.
    Oncogene. 2010 Sep 2,29(35):4885-95. doi: 10.1038/onc.2010.243. Epub 2010 Jul 5.

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  • 2010

    Erforschung der Chronisch Lymphatischen Leukämie am LIMCR.

    Hartmann TN.
    Med.ium. 6/2010.

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  • 2010

    ÖGHO-Frühjahrstagung: Chronische Lymphatische Leukämie, Adhäsionsmoleküle als mögliche therapeutische Ziele.

    Hartmann TN.
    JATROS Haematologie und Onkologie. 3/2010, Seite 63-65.

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  • 2010

    CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B.

    Leick M, Catusse J, Follo M, Nibbs RJ, Hartmann TN, Veelken H, Burger M.
    mmunology. 2010 Apr,129(4):536-46. doi: 10.1111/j.1365-2567.2009.03209.x. Epub 2009 Dec 2.

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  • 2009

    Novel therapeutics approaches to chronic lymphocytic leukemia based on recent biological insights.

    Hartmann TN, Pleyer L, Desch P, Egle A, Greil R.
    Discov Med. 2009 Oct,8(42):157-64.

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  • 2009

    Molecular and cellular mechanisms of CLL: novel therapeutic approaches.

    Pleyer L, Egle A, Hartmann TN, Greil R.
    Nat Rev Clin Oncol. 2009 Jul,6(7):405-18. doi: 10.1038/nrclinonc.2009.72. Epub 2009 Jun 2.

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  • 2009

    Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow.

    Hartmann TN, Grabovsky V, Wang W, Desch P, Rubenzer G, Wollner S, Binsky I, Vallon-Eberhard A, Sapoznikov A, Burger M, Shachar I, Haran M, Honczarenko M, Greil R, Alon R.
    Cancer Res. 2009 Apr 1,69(7):3121-30. doi: 10.1158/0008-5472.CAN-08-4136. Epub 2009 Mar 17.

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  • 2008

    A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells.

    Hartmann TN, Grabovsky V, Pasvolsky R, Shulman Z, Buss EC, Spiegel A, Nagler A, Lapidot T, Thelen M, Alon R.
    J Leukoc Biol. 2008 Oct,84(4):1130-40. doi: 10.1189/jlb.0208088. Epub 2008 Jul 24.

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"Leukemia cells are strongly dependent on the lymphoid tumor microenvironment, where they receive proliferative and pro-survival signals. We are interested in how CLL cells localize adjacent to these supportive signals."