Priv. Doz. OA Dr.
Alexander Egle
Senior physician
Okt 2013
Kongresssekretär der Gemeinsamen Jahrestagung der Österreichischen, Deutschen und Schweizer Gesellschaften für Hämatologie und Onkologie
Seit Apr 2010
Mitglied des wissenschaftlichen Komitees des Wissenschaftsfonds der Paracelsus Medizinischen Privatuniversität Salzburg
April 2009
Kongresssekretär der Frühjahrstagung der Österreichischen Gesellschaft für Hämatologie und Onkologie
Seit Nov 2006
Entwicklung und Management des klinischen GMP Stammzelllabors der III. medizinischen Abteilung der Salzburger Landeskliniken
Seit Feb 2006
Habilitation an der Paracelsus Medizinischen Privatuniversität Salzburg
Seit Sept 2005
Leiter der Infektiologischen Ambulanz der III. medizinischen Abteilung der Salzburger Landeskliniken
Jan 2005
Beginn der Lehrtätigkeit an der Paracelsus Medizinischen Privatuniversität Salzburg und Einreichung der Habilitationsschrift
Seit Nov 2004
Leiter der Laborgruppe für die Entwicklung muriner Lymphom Modelle
Seit Jan 2004
Leitung der Hämatologischen Ambulanz der III. Medizinischen Klinik der Salzburger Landeskliniken
Apr 2003 - Dez 2003
Rückkehr in das Facharztausbildungsprogramm der Klinik Innsbruck – Ernennung zum Facharzt für Innere Medizin
Nov 2002 - Mär 2003
Senior research officer level 5b am Walter and Eliza Hall Institut in Melbourne, Australien (Finanzierung durch NCI grant CA43540 und Leukemia and Lymphoma Society SCOR grant 7015)
Nov 2000 - Nov 2002
Erwin-Schrödinger Stipendiat des Österreichischen Wissenschaftsfonds FWF am Walter and Eliza Hall Institute of Medical Research unter der Führung von Prof. Suzanne Cory in der Abteilung für Molekulare Genetik von Krebs (Nummern J2129/J1921)
Aug 1996
Beginn der klinischen Ausbildung zum Facharzt für Innere Medizin an der Universitätsklinik für Innere Medizin Innsbruck
1993 - 2000
Postdoc-Stelle im Molekularzytologischen Labor der Universitätsklinik für Innere Medizin Innsbruck unter der Leitung von Prof Dr. Greil Richard
Jun 1993
Promotion zum Dr. med. an der Universität Innsbruck
1990 - 1993
Dissertation zum Thema "Zytostatische Wirkung von Inhibitoren der Protein Kinase C" am Institut für klinische Chemie und Biochemie an der Universität Innsbruck (Betreuer: Univ. Prof. Dr. H.H. Grunicke)
1987 - 1993
Medizinstudium an der Leopold Franzens Universität in Innsbruck
Forschungsförderungen
Ad personam
Univ. Innsbruck Forschungsstipendium
Hans and Blanca Moser Foundation
Erwin Schrödinger Stipendium des österreichischen FWF (Projekt J1921 und Folgeprojekt J2129)
Österreichische Nationalbank Projekt Number 10990
Forschungsförderung von Celgene Intl
Forschungsförderung der Paracelsus medizinischen Privatuniversität Salzburg in den Jahren 2010, 2011, 2012, 2013 und 2014 (laufend) Translationale Forschungsförderung durch den FWF (L488)
Mitantragsteller und Mentor im Firnberg-Programm des FWF (T671, laufend)
Internationale Forschungsförderung durch den FWF (I 1299, laufend)
Einzelprojektförderungen durch den FWF (P19481 - abgeschlossen und P26719 - laufend)
Beitrag
Österreichische Nationalbank
Eli Lilly Stiftung
US NCI (grant CA43540)
Leukemia and Lymphoma Society SCOR grant 7015
NHMRC (Canberra) program grant 257502
Auszeichnungen / Vorträge
Erstautor
Dissertationspreis der Hans und Blanca Moser Stiftung und der Stadt Dornbirn
Posterpreis der Österreichischen Gesellschaft für Hämatologie und Onkologie 1997
Auswahl als bester Abstract bei der Frühjahrstagung der Österreichischen Gesellschaft für Hämatologie und Onkologie 2003, Dornbirn mit Plenarvortrag
Auswahl als bester Abstract im Rahmen der Postersitzung der Österreichischen Gesellschaft für Hämatologie und Onkologie
Zahlreiche Vorträge bei nationalen und internationalen Kongressen unter anderem bei Tagungen der Deutschen/Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkolgie, der Deutschen CLL Studiengruppe und der Amerikanischen Gesellschaft für Hämatologie (ASH) Wissenschaftsmedaillen der Paracelsus Medizinischen Privatuniversität seit 2009
Koautor
AVENTIS Preis 1998 (Erstautor: Dr. Andreas Villunger)
AVENTIS Preis 1999 (Erstautor: Dr. Ingeborg Tinhofer)
Hoechst Preis 1998 (Erstautor: Dr. Andreas Villunger)
Hoechst Preis 1999 (Erstautor: Dr. Ingeborg Tinhofer)
Denk Preis 2000 (Erstautor: Dr. Ingeborg Tinhofer)
Türk Preis 2010 (Erstautor: Dr. Daniela Asslaber)
Sanofi Aventis Preis 2010 (Erstautor: Dr. Daniela Asslaber)
Sanofi Aventis Preis 2012 (Erstautor: Dr. Josefina Pinon-Hofbauer)
Review-Tätigkeit
Abstract Gutachter für mehrere ASH Meetings
Gutachter der Österreischen Nationalbank
Gutachter Cancer Research, UK
Journale:
Cell Death and Differentiation
Blood
Leukemia
PNAS
BMC Cancer
PLOS One
Bioassays
Annals Hematology
Cancer Research
Oncogene
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Novel models for prediction of benefit and toxicity with FOLFIRINOX treatment of pancreatic cancer using clinically available parameters.
Schlick, K, Magnes, T, Ratzinger, L, Jaud, B, Weiss, L, Melchardt, T, Greil, R, Egle, A.
PLoS One. 2018, 13(11): e0206688.
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Elevated amylase in plasma represents an adverse prognostic marker in patients with metastatic pancreatic cancer : A retrospective analysis.
Asamer, E, Szkandera, J, Gibiser, P, Lembeck, AL, Stojakovic, T, Kornprat, P, Lackner, C, Winder, T, Schlick, K, Stoger, H, Gerger, A, Pichler, M, Stotz, M.
WIEN KLIN WOCHENSCHR. 2018, 130(19-20): 569-574.
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Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development.
Zaborsky, N, Gassner, FJ, Höpner, JP, Schubert, M, Hebenstreit, D, Stark, R, Asslaber, D, Steiner, M, Geisberger, R, Greil, R, Egle, A.
Leukemia. 2018.
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Correction to: Fludarabine and rituximab with escalating doses of lenalidomide followed by lenalidomide/rituximab maintenance in previously untreated chronic lymphocytic leukaemia (CLL): the REVLIRIT CLL-5 AGMT phase I/II study.
Egle, A, Steurer, M, Melchardt, T, Weiss, L, Gassner, FJ, Zaborsky, N, Geisberger, R, Catakovic, K, Hartmann, TN, Pleyer, L, Voskova, D, Thaler, J, Lang, A, Girschikofsky, M, Petzer, A, Greil, R.
Ann Hematol. 2018.
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Remission maintenance treatment options in chronic lymphocytic leukemia.
Egle, A, Pleyer, L, Melchardt, T, Hartmann, TN, Greil, R.
Cancer Treat Rev. 2018, 70:5-66.
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Plitidepsin: a potential new treatment for relapsed/refractory multiple myeloma.
Leisch, M, Egle, A, Greil, R.
Future Oncol. 2018.
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Fludarabine and rituximab with escalating doses of lenalidomide followed by lenalidomide/rituximab maintenance in previously untreated chronic lymphocytic leukaemia (CLL): the REVLIRIT CLL-5 AGMT phase I/II study.
Egle, A, Steurer, M, Melchardt, T, Weiss, L, Gassner, FJ, Zaborsky, N, Geisberger, R, Catakovic, K, Hartman, TN, Pleyer, L, Voskova, D, Thaler, J, Lang, A, Girschikofsky, M, Petzer, A, Greil, R.
Ann Hematol. 2018.
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Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia.
Janovska, P, Verner, J, Kohoutek, J, Bryjova, L, Gregorova, M, Dzimkova, M, Skabrahova, H, Radaszkiewicz, T, Ovesna, P, Blanarova, OV, Nemcova, T, Hoferova, Z, Vasickova, K, Smyckova, L, Egle, A, Pavlova, S, Poppova, L, Plevova, K, Pospisilova, S, Bryja, V.
Blood. 2018, 131(11):1206-1218.
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DNA Methylation Signatures Predicting Bevacizumab Efficacy in Metastatic Breast Cancer.
Gampenrieder, SP, Rinnerthaler, G, Hackl, H, Pulverer, W, Weinhaeusel, A, Ilic, S, Hufnagl, C, Hauser-Kronberger, C, Egle, A, Risch, A, Greil, R.
THERANOSTICS. 2018, 8(8): 2278-2288.
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Clonal evolution and heterogeneity in metastatic head and neck cancer-An analysis of the Austrian Study Group of Medical Tumour Therapy study group.
Melchardt, T, Magnes, T, Hufnagl, C, Thorner, AR, Ducar, M, Neureiter, D, Tränkenschuh, W, Klieser, E, Gaggl, A, Rösch, S, Rasp, G, Hartmann, TN, Pleyer, L, Rinnerthaler, G, Weiss, L, Greil, R, Egle, A.
Eur J Cancer. 2018, 93:69-78.
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Establishment and validation of a novel risk model for estimating time to first treatment in 120 patients with chronic myelomonocytic leukaemia.
Huemer, F, Weiss, L, Faber, V, Neureiter, D, Egle, A, Geissler, K, Voskova, D, Zebisch, A, Burgstaller, S, Pichler, A, Stauder, R, Sperr, W, Lang, A, Pfeilstöcker, M, Machherndl-Spandl, S, Stampfl, M, Greil, R, Pleyer, L.
Wien Klin Wochenschr. 2018.
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Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia.
Gutjahr, JC, Szenes, E, Tschech, L, Asslaber, D, Schlederer, M, Roos, S, Yu, X, Girbl, T, Sternberg, C, Egle, A, Aberger, F, Alon, R, Kenner, L, Greil, R, Orian-Rousseau, V, Hartmann, TN.
Blood. 2018.
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Update on squamous cell carcinoma of the head and neck: ASCO annual meeting 2017.
Magnes, T, Egle, A, Greil, R, Melchardt, T.
Memo. 2017, 10(4):220-223.
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Red blood cell alloimmunization in 184 patients with myeloid neoplasms treated with azacitidine - A retrospective single center experience.
Leisch, M, Weiss, L, Lindlbauer, N, Jungbauer, C, Egle, A, Rohde, E, Greil, R, Grabmer, C, Pleyer, L.
Leuk Res. 2017, 59:12-19.
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Prognostic score in patients with recurrent or metastatic carcinoma of the head and neck treated with cetuximab and chemotherapy.
Magnes, T, Melchardt, T, Weiss, L, Mittermair, C, Neureiter, D, Klieser, E, Gampenrieder, S, Moser, G, Gaggl, A, Greil, R, Egle, A.
PLoS One. 2017, 12(7):e0180995.
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The influence of FCGR2A and FCGR3A polymorphisms on the survival of patients with recurrent or metastatic squamous cell head and neck cancer treated with cetuximab.
Magnes, T, Melchardt, T, Hufnagl, C, Weiss, L, Mittermair, C, Neureiter, D, Klieser, E, Rinnerthaler, G, Roesch, S, Gaggl, A, Greil, R, Egle, A.
Pharmacogenomics J. 2017.
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Ristocetin-induced platelet aggregation for monitoring of bleeding tendency in CLL treated with ibrutinib.
Kazianka, L, Drucker, C, Skrabs, C, Thomas, W, Melchardt, T, Struve, S, Bergmann, M, Staber, PB, Porpaczy, E, Einberger, C, Heinz, M, Hauswirth, A, Raderer, M, Pabinger, I, Thalhammer, R, Egle, A, Wendtner, CM, Follows, G, Hoermann, G, Quehenberger, P, Jilma, B, Jaeger, U.
Leukemia. 2017, 31(5):1117-1122.
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Milestones in Chronic Lymphocytic Leukemia: An exciting decade of progress-10th anniversary of memo.
Egle, A.
Memo. 2017, 10(1):8-12.
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Influence of body mass index on survival in indolent and mantle cell lymphomas: analysis of the StiL NHL1 trial.
Weiss, L, Melchardt, T, Egle, A, Hopfinger, G, Hackl, H, Greil, R, Barth, J, Rummel, M.
Ann Hematol. 2017.
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A phase 2 study of rituximab plus lenalidomide for mucosa-associated lymphoid tissue lymphoma.
Kiesewetter, B, Willenbacher, E, Willenbacher, W, Egle, A, Neumeister, P, Voskova, D, Mayerhoefer, ME, Simonitsch-Klupp, I, Melchardt, T, Greil, R, Raderer, M.
Blood. 2017, 129(3):383-385
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Rituximab maintenance versus observation alone in patients with chronic lymphocytic leukaemia who respond to first-line or second-line rituximab-containing chemoimmunotherapy: final results of the AGMT CLL-8a Mabtenance randomised trial.
Greil, R, ObrtlÃková, P, Smolej, L, Kozák, T, Steurer, M, Andel, J, Burgstaller, S, MikuÅ¡ková, E, Gercheva, L, Nösslinger, T, PapajÃk, T, Ladická, M, Girschikofsky, M, HrubiÅ¡ko, M, Jäger, U, Fridrik, M, Pecherstorfer, M, Králiková, E, Burcoveanu, C, Spasov, E, Petzer, A, Mihaylov, G, Raynov, J, Oexle, H, Zabernigg, A, Flochová, E, Palášthy, S, StehlÃková, O, Doubek, M, Altenhofer, P, Pleyer, L, Melchardt, T, Klingler, A, Mayer, J, Egle, A.
Lancet Haematol. 2016, 3(7): e317-e329.
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Bcl-2 proteins in development, health, and disease of the hematopoietic system.
Kollek, M, Müller, A, Egle, A, Erlacher, M.
FEBS J. 2016, 283(15): 2779-2810.
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Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones.
Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
Oncotarget. 2016, xx:
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NCCN-IPI score-independent prognostic potential of pretreatment uric acid levels for clinical outcome of diffuse large B-cell lymphoma patients.
Prochazka, KT, Melchardt, T, Posch, F, Schlick, K, Deutsch, A, Beham-Schmid, C, Weiss, L, Gary, T, Neureiter, D, Klieser, E, Greil, R, Neumeister, P, Egle, A, Pichler, M.
Br J Cancer. 2016, xx:
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Fluorouracil and Dihydropyrimidine Dehydrogenase Genotyping.
Magnes, T, Melchardt, T, Weiss, L, Hufnagl, C, Greil, R, Egle, A.
J Clin Oncol. 2016, 34(20): 2433-2434.
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Intermittent low-dose bevacizumab in hereditary hemorrhagic telangiectasia : A case report.
Huemer, F, Dejaco, M, Grabmer, C, Melchardt, T, Neureiter, D, Mayer, G, Egle, A, Greil, R, Weiss, L.
Wien Klin Wochenschr. 2016,
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Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality?.
Zaborsky, N, Gassner, FJ, Asslaber, D, Reinthaler, P, Denk, U, Flenady, S, Hofbauer, JP, Danner, B, Rebhandl, S, Harrer, A, Geisberger, R, Greil, R, Egle, A.
Oncotarget. 2016,
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An international, multicenter, prospective, observational study of neutropenia in patients being treated with lenalidomide?+?dexamethasone for relapsed or relapsed/refractory multiple myeloma (RR-MM).
Kollek, M, Müller, A, Egle, A, Erlacher, M.
FEBS J. 2016, 283(15):2779-2810
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Developing a cancer immunogene therapy approach for Epidermolysis bullosa-associated squamous cell carcinoma.
Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
Oncotarget. 2016,
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CRISPR/Cas9-mediated gene repair in the COL7A1 gene.
Prochazka, KT, Melchardt, T, Posch, F, Schlick, K, Deutsch, A, Beham-Schmid, C, Weiss, L, Gary, T, Neureiter, D, Klieser, E, Greil, R, Neumeister, P, Egle, A, Pichler, M.
Br J Cancer. 2016,
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Bcl-2 proteins in development, health, and disease of the hematopoietic system.
Kollek, M, Müller, A, Egle, A, Erlacher, M.
FEBS J. 2016, 283(15):2779-2810
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CD1d expression on chronic lymphocytic leukemia B cells affects disease progression and induces T cell skewing in CD8 positive and CD4CD8 double negative T cells.
Zaborsky, N, Gassner, FJ, Asslaber, D, Reinthaler, P, Denk, U, Flenady, S, Hofbauer, JP, Danner, B, Rebhandl, S, Harrer, A, Geisberger, R, Greil, R, Egle, A.
Oncotarget. 2016,
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Fluorouracil and Dihydropyrimidine Dehydrogenase Genotyping.
Magnes, T, Melchardt, T, Weiss, L, Hufnagl, C, Greil, R, Egle, A.
J Clin Oncol. 2016, 34(20):2433-2434
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Depletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo.
Hanna, BS, McClanahan, F, Yazdanparast, H, Zaborsky, N, Kalter, V, Rößner, PM, Benner, A, Dürr, C, Egle, A, Gribben, JG, Lichter, P, Seiffert, M.
Leukemia. 2016, 30(3): 570-579.
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The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma.
Troppan, KT, Melchardt, T, Wenzl, K, Schlick, K, Deutsch, A, Bullock, MD, Reitz, D, Beham-Schmid, C, Weiss, L, Neureiter, D, Tränkenschuh, W, Greil, R, Neumeister, P, Egle, A, Pichler, M.
J Clin Pathol. 2016, 69(4):326-330.
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ILK Induction in Lymphoid Organs by a TNFα-NF-κB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia.
Krenn, PW, Hofbauer, SW, Pucher, S, Hutterer, E, Hinterseer, E, Denk, U, Asslaber, D, Ganghammer, S, Sternberg, C, Neureiter, D, Aberger, F, Wickström, SA, Egle, A, Greil, R, Hartmann, TN.
Cancer Res. 2016, 76(8):2186-2196.
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The AKT1 isoform plays a dominant role in the survival and chemoresistance of chronic lymphocytic leukaemia cells.
Hofbauer, SW, Krenn, PW, Piñόn Hofbauer, J, Pucher, S, Asslaber, D, Egle, A, Hartmann, TN, Greil, R.
Br J Haematol. 2016, 172(5): 815-819.
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A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study.
"Rawstron, AC, Fazi, C, Agathangelidis, A, Villamor, N, Letestu, R, Nomdedeu, J, Palacio, C, Stehlikova, O, Kreuzer, KA, Liptrot, S, O""Brien, D, de Tute, RM, Marinov, I, Hauwel, M, Spacek, M, Dobber, J, Kater, AP, Gambell, P, Soosapilla, A, Lozanski, G, Brachtl, G, Lin, K, Boysen, J, Hanson, C, Jorgensen, JL, Stetler-Stevenson, M, Yuan, C, Broome, HE, Rassenti, L, Craig, F, Delgado, J, Moreno, C, Bosch, F, Egle, A, Doubek, M, Pospisilova, S, Mulligan, S, Westerman, D, Sanders, CM, Emerson, R, Robins, HS, Kirsch, I, Shanafelt, T, Pettitt, A.Kipps, TJ, Wierda, WG, Cymbalista, F, Hallek, M, Hillmen, P, Montserrat, E, Ghia, P."
Leukemia. 2016, 30(4):929-936.
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Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones.
Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
Oncotarget. 2016.
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The significance of pretreatment anemia in the era of R-IPI and NCCN-IPI prognostic risk assessment tools: a dual-center study in diffuse large B-cell lymphoma patients.
Troppan, KT, Melchardt, T, Deutsch, A, Schlick, K, Stojakovic, T, Bullock, MD, Reitz, D, Beham-Schmid, C, Weiss, L, Neureiter, D, Wenzl, K, Greil, R, Neumeister, P, Egle, A, Pichler, M.
Eur J Haematol. 2015, 95(6): 538-544.
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CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.
Kocher, T, Asslaber, D, Zaborsky, N, Flenady, S, Denk, U, Reinthaler, P, Ablinger, M, Geisberger, R, Bauer, JW, Seiffert, M, Hartmann, TN, Greil, R, Egle, A, Hofbauer, JP.
Leukemia. 2015, xx.
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Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.
Sochalska, M, Tuzlak, S, Egle, A, Villunger, A.
FEBS J. 2015, 282(5): 834-849.
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A modified scoring of the NCCN-IPI is more accurate in the elderly and is improved by albumin and β2 -microglobulin.
Melchardt, T, Troppan, K, Weiss, L, Hufnagl, C, Neureiter, D, Tränkenschuh, W, Hopfinger, G, Magnes, T, Deutsch, A, Neumeister, P, Hackl, H, Greil, R, Pichler, M, Egle, A.
Br J Haematol. 2015, 168(2):239-245.
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Treatment of aggressive B-cell lymphoma in elderly patients: influence of single nucleotide polymorphisms affecting pharmacodynamics of chemotherapeutics.
Melchardt, T, Weiss, L, Hufnagl, C, Neureiter, D, Kemmerling, R, Morre, P, Boekstegers, A, Hopfinger, G, Auberger, J, Steinkirchner, S, Pleyer, L, Greil, R, Egle, A.
Leuk Lymphoma. 2015, 56(2):353-360.
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Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b.
Them, NC, Bagienski, K, Berg, T, Gisslinger, B, Schalling, M, Chen, D, Buxhofer-Ausch, V, Thaler, J, Schloegl, E, Gastl, GA, Wolf, D, Strecker, K, Egle, A, Melchardt, T, Burgstaller, S, Willenbacher, E, Zagrijtschuk, O, Klade, C, Greil, R, Gisslinger, H, Kralovics, R.
Am J Hematol. 2015, 90(4): 288-294.
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B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia.
Zaborsky, N, Holler, C, Geisberger, R, Asslaber, D, Gassner, FJ, Egger, V, Piñón-Hofbauer, J, Kocher, T, Hartmann, TN, Greil, R, Egle, A.
Haematologica. 2015, 100(8): e307-e310.
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Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model.
Gassner FJ, Zaborsky N, Catakovic K, Rebhandl S, Huemer M, Egle A, Hartmann TN, Greil R, Geisberger R.
Br J Haematol. 2015 Aug,170(4):515-22. doi: 10.1111/bjh.13467. Epub 2015 May 4.
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Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial.
Gnant, M, Pfeiler, G, Dubsky, PC, Hubalek, M, Greil, R, Jakesz, R, Wette, V, Balic, M, Haslbauer, F, Melbinger, E, Bjelic-Radisic, V, Artner-Matuschek, S, Fitzal, F, Marth, C, Sevelda, P, Mlineritsch, B, Steger, GG, Manfreda, D, Exner, R, Egle, D, Bergh, J, Kainberger, F, Talbot, S, Warner, D, Fesl, C, Singer, CF.
LANCET. 2015, 386(9992): 433-443.
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CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21.
Ganghammer, S, Hutterer, E, Hinterseer, E, Brachtl, G, Asslaber, D, Krenn, PW, Girbl, T, Berghammer, P, Geisberger, R, Egle, A, Zucchetto, A, Kruschinski, A, Gattei, V, Chigaev, A, Greil, R, Hartmann, TN.
Oncotarget. 2015, 6(14): 12048-12060.
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CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer.
Melchardt, T, Hufnagl, C, Magnes, T, Weiss, L, Hutarew, G, Neureiter, D, Schlattau, A, Moser, G, Gaggl, A, Tränkenschuh, W, Greil, R, Egle, A.
BMC Cancer. 2015, 15:725
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Independent Prognostic Value of Serum Markers in Diffuse Large B-Cell Lymphoma in the Era of the NCCN-IPI.
Melchardt, T, Troppan, K, Weiss, L, Hufnagl, C, Neureiter, D, Tränkenschuh, W, Schlick, K, Huemer, F, Deutsch, A, Neumeister, P, Greil, R, Pichler, M, Egle, A.
J Natl Compr Canc Netw. 2015, 13(12):1501-1508
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Ropeginterferon alfa-2b, a novel IFNα-2b, induces high response rates with low toxicity in patients with polycythemia vera.
Gisslinger, H, Zagrijtschuk, O, Buxhofer-Ausch, V, Thaler, J, Schloegl, E, Gastl, GA, Wolf, D, Kralovics, R, Gisslinger, B, Strecker, K, Egle, A, Melchardt, T, Burgstaller, S, Willenbacher, E, Schalling, M, Them, NC, Kadlecova, P, Klade, C, Greil, R.
Blood. 2015, 126(15): 1762-1769.
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Anti-Hu Antibody Associated Paraneoplastic Cerebellar Degeneration in Head and Neck Cancer.
Huemer, F, Melchardt, T, Tränkenschuh, W, Neureiter, D, Moser, G, Magnes, T, Weiss, L, Schlattau, A, Hufnagl, C, Ricken, G, Höftberger, R, Greil, R, Egle, A.
BMC Cancer. 2015, 15:996
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Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia.
Gassner FJ, Zaborsky N, Neureiter D, Huemer M, Melchardt T, Egle A, Rebhandl S, Catakovic K, Hartmann TN, Greil R, Geisberger R.
Haematologica. 2014 May,99(5):67-9. doi: 10.3324/haematol.2013.098459. Epub 2014 Feb 21.
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Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade.
Grössinger EM, Weiss L, Zierler S, Rebhandl S, Krenn PW, Hinterseer E, Schmölzer J, Asslaber D, Hainzl S, Neureiter D, Egle A, Piñón-Hofbauer J, Hartmann TN, Greil R, Kerschbaum HH.
Leukemia. 2014 Apr,28(4):954-8. doi: 10.1038/leu.2014.37. Epub 2014 Jan 20.
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Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b.
Them NC, Bagienski K, Berg T, Gisslinger B, Schalling M, Chen D, Buxhofer-Ausch V, Thaler J, Schloegl E, Gastl GA, Wolf D, Strecker K, Egle A, Melchardt T, Burgstaller S, Willenbacher E, Zagrijtschuk O, Klade C, Greil R, Gisslinger H, Kralovics R.
Am J Hematol. 2015 Apr,90(4):288-94. doi: 10.1002/ajh.23928. Epub 2015 Mar 2.
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A modified scoring of the NCCN-IPI is more accurate in the elderly and is improved by albumin and β(2) -microglobulin.
Melchardt T, Troppan K, Weiss L, Hufnagl C, Neureiter D, Tränkenschuh W, Hopfinger G, Magnes T, Deutsch A, Neumeister P, Hackl H, Greil R, Pichler M, Egle A.
Br J Haematol. 2015 Jan,168(2):239-45. doi: 10.1111/bjh.13116. Epub 2014 Sep 19.
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Kasabach-Merritt phenomenon in hepatic angiosarcoma.
Habringer S, Boekstegers A, Weiss L, Hopfinger G, Meissnitzer T, Melchardt T, Egle A, Greil R.
Br J Haematol. 2014 Dec,167(5):716-8. doi: 10.1111/bjh.13049. Epub 2014 Jul 24.
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C-reactive protein level is a prognostic indicator for survival and improves the predictive ability of the R-IPI score in diffuse large B-cell lymphoma patients.
Troppan KT, Schlick K, Deutsch A, Melchardt T, Egle A, Stojakovic T, Beham-Schmid C, Weiss L, Neureiter D, Wenzl K, Greil R, Neumeister P, Pichler M.
Br J Cancer. 2014 Jul 8,111(1):55-60. doi: 10.1038/bjc.2014.277. Epub 2014 May 29.
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Treatment of aggressive B-cell lymphoma in elderly patients: influence of single nucleotide polymorphisms affecting pharmacodynamics of chemotherapeutics.
Melchardt T, Weiss L, Hufnagl C, Neureiter D, Kemmerling R, Morre P, Boekstegers A, Hopfinger G, Auberger J, Steinkirchner S, Pleyer L, Greil R, Egle A.
Leuk Lymphoma. 2015 Feb,56(2):353-60. doi: 10.3109/10428194.2014.916798. Epub 2014 Jun 25.
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Liver toxicity during temozolomide chemotherapy caused by Chinese herbs.
Melchardt T, Magnes T, Weiss L, Grundbichler M, Strasser M, Hufnagl C, Moik M, Greil R, Egle A.
BMC Complement Altern Med. 2014 Mar 30,14:115. doi: 10.1186/1472-6882-14-115.
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Human immunodeficiency virus type 2 infections in Austria.
Taylor N, Kern JM, Prammer W, Lang A, Haas B, Gisinger M, Zangerle R, Egle A, Greil R, Oberkofler H, Eberle J.
Wien Klin Wochenschr. 2014 Apr,126(7-8):212-6. doi: 10.1007/s00508-013-0493-1. Epub 2014 Jan 18.
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Lenalidomide in combination with vorinostat and dexamethasone for the treatment of relapsed/refractory peripheral T cell lymphoma (PTCL): report of a phase I/II trial.
Hopfinger G, Nösslinger T, Lang A, Linkesch W, Melchardt T, Weiss L, Egle A, Greil R.
Ann Hematol. 2014 Mar,93(3):459-62. doi: 10.1007/s00277-014-2009-0. Epub 2014 Jan 18.
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Increased body mass index is associated with improved overall survival in diffuse large B-cell lymphoma.
Weiss L, Melchardt T, Habringer S, Boekstegers A, Hufnagl C, Neureiter D, Hopfinger G, Greil R, Egle A.
Ann Oncol. 2014 Jan,25(1):171-6. doi: 10.1093/annonc/mdt481. Epub 2013 Dec 3.
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Pleural decortication of a marginal zone lymphoma.
Melchardt T, Weiss L, Namberger K, Pretsch I, Hutter J, Rettenbacher L, Neureiter D, Troch M, Greil R, Egle A.
Ann Hematol. 2014 Jul,93(7):1253-4. doi: 10.1007/s00277-013-1960-5. Epub 2013 Nov 22.
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"Old and new news in CLL: ""It""s the pathway, stupid!""."
Egle, A,
Blood. 2014 Aug 14,124(7):989-90. doi: 10.1182/blood-2014-05-574145.
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How does lenalidomide target the chronic lymphocytic leukemia microenvironment?
Kater, AP, Tonino, SH, Egle, A, Ramsay, AG,
Blood. 2014 Oct 2,124(14):2184-9. doi: 10.1182/blood-2014-05-578286. Epub 2014 Aug 26.
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Lenalidomide/Rituximab Maintenance After Induction With Fludarabine/Rituximab In Combination With Escalating Doses Of Lenalidomide In Previously Untreated Chronic Lymphocytic Leukemia (CLL): The Revlirit CLL5 AGMT Phase I/II Study, Final Results
Vornamen sind ausgeschrieben-ändern? Alexander Egle, Michael Steurer, Franz Josef Gassner, Roland Geisberger, Thomas Melchardt, Lisa Pleyer, Lukas Weiss, Michael A. Fridrik, Josef Thaler, Alois Lang, Richard Greil,
Blood (ASH Annual Meeting Abstracts). 2013. #4164:
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Blockade of the Potassium Channel KCa3.1 inhibits proliferation in Chronic Lymphocytic Leukemia
Grossinger, EM, Weiss, L, Zierler, S, Hinterseer, E, Schmolzer, J, Asslaber, D, Hainzl, S, Egle, A, Pinon, JD, Hartmann, TN, Greil, R, Kerschbaum, HH
ONKOLOGIE. 2013, 36: 191-192.
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The transcription factor IRF-4 is related to prognosis in Chronic Lymphocytic Leukemia (CLL) and involved in proliferation and survival
Asslaber, D, Hofbauer, JP, Zaborsky, N, Kocher, T, Hartmann, TN, Greil, R, Egle, A
ONKOLOGIE. 2013, 36: 222-223.
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Mimicking the microenvironment in chronic lymphocytic leukaemia - where does the journey go?
Asslaber D, Grössinger EM, Girbl T, Hofbauer SW, Egle A, Weiss L, Greil R, Hartmann TN.
Br J Haematol. 2013 Mar,160(5):711-4. doi: 10.1111/bjh.12151. Epub 2012 Dec 4.
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Complications of 5-azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome.
Melchardt T, Weiss L, Pleyer L, Steinkirchner S, Auberger J, Hopfinger G, Greil R, Egle A.
Oncol Lett. 2013 Dec,6(6):1756-1758. Epub 2013 Oct 15.
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Cobas ampliprep/cobas TaqMan HIV-1 v2.0 assay: consequences at the cohort level.
Taylor N, Grabmeier-Pfistershammer K, Egle A, Greil R, Rieger A, Ledergerber B, Oberkofler H.
PLoS One. 2013 Aug 30,8(8):e74024. doi: 10.1371/journal.pone.0074024. eCollection 2013.
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Azacitidine in patients with WHO-defined AML - results of 155 patients from the Austrian Azacitidine Registry of the AGMT-Study Group.
Pleyer L, Stauder R, Burgstaller S, Schreder M, Tinchon C, Pfeilstocker M, Steinkirchner S, Melchardt T, Mitrovic M, Girschikofsky M, Lang A, Krippl P, Sliwa T, Egle A, Linkesch W, Voskova D, Angermann H, Greil R.
J Hematol Oncol. 2013 Apr 29,6:32. doi: 10.1186/1756-8722-6-32.
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Use of romiplostim allows for hepatitis C therapy in a HIV/HCV coinfected patient.
Taylor N, Melchardt T, Grundbichler M, Strasser M, Egle A, Greil R.
Ann Hematol. 2013 Jul,92(7):1001-2. doi: 10.1007/s00277-012-1659-z. Epub 2012 Dec 28.
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Viral infections and their management in patients with chronic lymphocytic leukemia.
Melchardt T, Weiss L, Greil R, Egle A.
Leuk Lymphoma. 2013 Aug,54(8):1602-13. doi: 10.3109/10428194.2012.755178. Epub 2013 Jan 3.
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What’s new in Hodgkin’s lymphoma: ASH 2012 and more
Melchardt, T, Weiss, L, Greil, R, Egle, A,
Magazine of European Medical Oncology. 2013, Volume 6, Issue 3: 193-196.
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Influence of Body Mass Index on survival in indolent and Mantle-cell Lymphomas: Analysis of the StiL1 trial
Weiss, L, Melchardt, T, Egle, A, Hopfinger, G, Greil, R, Barth, J, Rummel, M
ONKOLOGIE. 2013, 36: 31-32.
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[Autoimmune hemolysis accompanied by thrombopenia: consumption or myelodysplasia?].
Melchardt, T, Weiss, L, Egle, A,
Dtsch Med Wochenschr. 2013 Oct,138(41):2093-5. doi: 10.1055/s-0033-1349586. Epub 2013 Oct 1.
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Bid-ding for mercy: twisted killer in action.
Egle A, Asslaber D, Villunger A, Pinon-Hofbauer J.
Cell Death and Differentiation. 2013 Jul,20(7):847-9. doi: 10.1038/cdd.2013.40.
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p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa.
Valente LJ, Gray DH, Michalak EM, Pinon-Hofbauer J, Egle A, Scott CL, Janic A, Strasser A.
Cell Rep. 2013 May 30,3(5):1339-45. doi: 10.1016/j.celrep.2013.04.012. Epub 2013 May 9.
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Protein Kinase C-?-Dependent Activation of NF-?B in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo.
Lutzny G, Kocher T, Schmidt-Supprian M, Rudelius M, Klein-Hitpass L, Finch AJ, Dürig J, Wagner M, Haferlach C, Kohlmann A, Schnittger S, Seifert M, Wanninger S, Zaborsky N, Oostendorp R, Ruland J, Leitges M, Kuhnt T, Schäfer Y, Lampl B, Peschel C, Egle A, Ringshausen I.
Cancer Cell. 2013 Jan 14,23(1):77-92. doi: 10.1016/j.ccr.2012.12.003.
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Lysine residue at position 22 of the AID protein regulates its class switch activity.
Geisberger R, Huemer M, Gassner FJ, Zaborsky N, Egle A, Greil R.
PLoS One. 2012,7(2):e30667. doi: 10.1371/journal.pone.0030667. Epub 2012 Feb 20.
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Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.
Merkel O, Wacht N, Sifft E, Melchardt T, Hamacher F, Kocher T, Denk U, Hofbauer JP, Egle A, Scheideler M, Schlederer M, Steurer M, Kenner L, Greil R.
Leukemia. 2012 Dec,26(12):2508-16. doi: 10.1038/leu.2012.147. Epub 2012 Jun 1.
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Treatment of Aggressive B-Cell Lymphoma in the Elderly: The Influence of SNPs Affecting Pharmacodynamics Is Different Compared to Younger Patient
Thomas Melchardt, Lukas Weiss, Clemens Hufnagl, Daniel Neureiter, Ralf Kemmerling, Patrick Morre, Ann Boekstegers, Georg Hopfinger, Richard Greil, Alexander Egle,
Blood (ASH Annual Meeting Abstracts) 2012. 2012. #1613:
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Feasibility of anthracycline based treatment in unselected elderly DLBCL patients
Melchardt, T, Weiss, L, Hufnagl, C, Neureiter, D, Kemmerling, R, Hopfinger, G, Greil, R, Egle, A
ONKOLOGIE. 2012, 35: 86-87.
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Complications of 5-azacytidine: Three cases of severe colitis in a single center cohort
Melchardt, T, Weiss, L, Pleyer, L, Steinkirchner, S, Greil, R, Egle, A
ONKOLOGIE. 2012, 35: 149-149.
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Treatment of Aggressive B-Cell Lymphoma in the Elderly: The Influence of SNPs Affecting Pharmacodynamics Is Different Compared to Younger Patient
Melchardt, T, Weiss, L, Hufnagl, C, Neureiter, D, Kemmerling, R, Morre, P, Boekstegers, A, Hopfinger, G, Greil, R, Egle, A
BLOOD. 2012, 120(21):
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AOP2014, a Novel Peg-Proline-Interferon Alpha-2b with Improved Pharmacokinetic Properties, Is Safe and Well Tolerated and Shows Promising Efficacy in Patients with Polycythemia Vera (PV)
Gisslinger, H, Kralovics, R, Gisslinger, B, Lechner, D, Buxhofer-Ausch, V, Strecker, K, Gastl, G, Willenbacher, E, Greil, R, Egle, A, Melchardt, T, Burgstaller, S, Schloegl, E, Tarmann, FJ, Zoerer, M, Klade, C, Zahriychuk, O, Thaler, J
BLOOD. 2012, 120(21):
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Upgraded Cobas TaqMan version 2: hidden consequences at cohort level
Taylor, N, Grabmeier-Pfistershammer, K, Oberkofler, H, Egle, A, Rieger, A, Ledergerber, B
J INT AIDS SOC. 2012, 15: 109-109.
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Fludarabine modulates composition and function of the T cell pool in patients with chronic lymphocytic leukaemia.
Gassner FJ, Weiss L, Geisberger R, Hofbauer JP, Egle A, Hartmann TN, Greil R, Tinhofer I.
Cancer Immunol Immunother. 2011 Jan,60(1):75-85. doi: 10.1007/s00262-010-0920-3. Epub 2010 Sep 21.
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A Combination of Fludarabine/Rituximab with Escalating Doses of Lenalidomide in Previously Untreated Chronic Lymphocytic Leukemia (CLL): The REVLIRIT CLL5 AGMT Phase I/II Study, Clinical and Exploratory Analyses of Induction Results
Egle, A, Steurer, M, Gassner, F, Geisberger, R, Melchardt, T, Weiss, L, Fridrik, MA, Thaler, J, Lang, A, Greil, R
BLOOD. 2011, 118(21): 135-136.
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Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells.
Brachtl G, Sahakyan K, Denk U, Girbl T, Alinger B, Hofbauer SW, Neureiter D, Hofbauer JP, Egle A, Greil R, Hartmann TN.
PLoS One. 2011,6(8):e23758. doi: 10.1371/journal.pone.0023758. Epub 2011 Aug 18.
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Complete remission of Waldenström macroglobulinemia with azacitidine and rituximab.
Weiss L, Melchardt T, Neureiter D, Kemmerling R, Moshir S, Pleyer L, Greil R, Egle A.
J Clin Oncol. 2011 Aug 20,29(24):e696-8. doi: 10.1200/JCO.2011.35.8283. Epub 2011 Jul 5.
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Raltegravir in pregnancy: a case series presentation.
Taylor N, Touzeau V, Geit M, Gisinger M, Egle A, Greil R, Rieger A, Zangerle R.
Int J STD AIDS. 2011 Jun,22(6):358-60. doi: 10.1258/ijsa.2011.010469.
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Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL.
Hofbauer JP, Heyder C, Denk U, Kocher T, Holler C, Trapin D, Asslaber D, Tinhofer I, Greil R, Egle A.
Leukemia. 2011 Sep,25(9):1452-8. doi: 10.1038/leu.2011.111. Epub 2011 May 24.
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Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia.
Weiss L, Melchardt T, Egle A, Grabmer C, Greil R, Tinhofer I.
Cancer. 2011 May 15,117(10):2163-9. doi: 10.1002/cncr.25752. Epub 2010 Nov 18.
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Treatment of invasive aspergillosis in cancer patients.
Auberger, J, Russ, G, Greil, R, Egle, A,
memo - Magazine of European Medical Oncology. 2011, 4 (4): 266-272.
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Activity of Azacitidine in 26 Unselected, Consecutive CMML Patients Included in the Austrian Azacitidine Registry (AAR) of the AGMT-Study Group
Pleyer, L, Stauder, R, Burgstaller, S, Schreder, M, Tinchon, C, Pfeilstocker, M, Steinkirchner, S, Melchardt, T, Mitrovic, M, Girschikofsky, M, Lang, A, Krippl, P, Egle, A, Sliwa, T, Linkesch, W, Fridrik, MA, Greil, R
BLOOD. 2011, 118(21): 747-747.
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Open-Label, Prospective, Multicentre, Phase I/II Study of AOP2014, a Novel PEG-Proline-Interferon Alpha-2b in Patients with Polycythemia Vera: Update from an Ongoing Study
Gisslinger, H, Kralovics, R, Schoder, R, Gisslinger, B, Buxhofer-Ausch, V, Strecker, K, Wolf, D, Willenbacher, E, Greil, R, Egle, A, Melchardt, T, Burgstaller, S, Tarmann, FJ, Wachter, C, Zahriycick, O, Thaler, J
BLOOD. 2011, 118(21): 762-762.
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Tumor load reduction and prolongation of overall-survival by actinomycin D in a murine model of high-risk chronic lymphocytic leukemia
Wacht, N, Sifft, E, Melchardt, T, Hamacher, F, Denk, U, Pinon-Hofbauer, J, Egle, A, Kocher, T, Steurer, M, Greil, R, Merkel, O
ONKOLOGIE. 2011, 34: 141-141.
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CLL CELLS INDUCE CLONAL T CELL SKEWING AND SUBSETSHIFTING IN THE MURINE TCL1 TRANSGENIC CHRONIC LYMPHOCYTIC LEUKEMIA MODEL
Egle, A, Pinon-Hofbauer, J, Heyder, C, Denk, U, Kocher, T, Holler, C, Trapin, D, Asslaber, D, Tinhofer, I, Greil, R
ANN ONCOL. 2011, 22: 144-144.
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Clonal Diversity of the T Cell Repertoire Predicts Disease Progression in Chronic Lymphocytic Leukaemia
Holler, C, Zaborsky, N, Hofbauer, JP, Kocher, T, Trapin, D, Asslaber, D, Greil, R, Egle, A
BLOOD. 2011, 118(21): 365-365.
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Clinical aspects of 2009 pandemic influenza A (H1N1) virus infection in Austria.
Poeppl, W, Hell, M, Herkner, H, Stoiser, B, Fritsche, G, Schurz-Bamieh, N, Poeppl, G, Gattringer, R, Jones, N, Maass, M, Egle, A, Burgmann, H,
Infection. 2011 Aug,39(4):341-52. doi: 10.1007/s15010-011-0121-9. Epub 2011 May 5.
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MicroRNAs as biomarkers for the diagnosis and prognosis of human cancer.
Asslaber D, Pinon Hofbauer J, Greil R, Egle A.
Journal of Nucleic Acids Investigations. 2010, Dec 1, 1(1): 76-80.
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An uncommon cause of anaemia: Sheehan's syndrome.
Melchardt T, Namberger K, Weiss L, Egle A, Faber V, Greil R.
Wien Klin Wochenschr. 2010 Dec,122(23-24):717-9. doi: 10.1007/s00508-010-1480-4. Epub 2010 Dec 7.
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Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia.
Merkel O, Asslaber D, Piñón JD, Egle A, Greil R.
Cell Cycle. 2010 Jul 15,9(14):2764-8. Epub 2010 Jul 3.
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microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia.
Asslaber D, Piñón JD, Seyfried I, Desch P, Stöcher M, Tinhofer I, Egle A, Merkel O, Greil R.
Blood. 2010 May 27,115(21):4191-7. doi: 10.1182/blood-2009-07-234823. Epub 2010 Jan 20.
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Enzastaurin kills human CLL cells regardless of clinical risk profile, but fails to prolong life in a murine CLL model
Kocher, T, Pinon, HJ, Holler, C, Denk, U, Greil, R, Egle, A
ONKOLOGIE. 2010, 33: 40-40.
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Final Analysis of Induction Treatment with Fludarabine, Cyclophosphamide Plus Rituximab (FCR) Followed by Fludarabine Plus Rituximab (FR) and Remission Maintenance Therapy with Rituximab In Previously Untreated B-Chronic Lymphocytic Leukemia (B-CLL): The Chairos AGMT CLL4/Roche ML18434 Study
Egle, A, Weiss, L, Melchardt, T, Gunsilius, E, Petzer, AL, Fridrik, M, Lang, A, Krieger, O, Thaler, J, Greil, R
BLOOD. 2010, 116(21): 593-594.
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Deletion of Puma and p21(Waf1) In Mice Deactivates p53-Induced Cell Death and Cell Cycle Arrest, but Protects Mice From Irradiation-Induced Lymphomagenesis by a Mechanism Involving Hemopoietic Stem Cell Quiescence
Hofbauer, JP, Holler, C, Denk, U, Asslaber, D, Fastner, G, Labi, V, Villunger, A, Greil, R, Egle, A
BLOOD. 2010, 116(21): 45-46.
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Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation.
Labi V, Erlacher M, Krumschnabel G, Manzl C, Tzankov A, Pinon J, Egle A, Villunger A.
Genes Dev. 2010 Aug 1,24(15):1602-7. doi: 10.1101/gad.1940210.
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Riding the 2-edged sword.
Egle A.
Blood. 2010 Jun 3,115(22):4325-6. doi: 10.1182/blood-2010-03-272211.
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Novel therapeutics approaches to chronic lymphocytic leukemia based on recent biological insights.
Hartmann TN, Pleyer L, Desch P, Egle A, Greil R.
Discov Med. 2009 Oct,8(42):157-64.
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Molecular and cellular mechanisms of CLL: novel therapeutic approaches.
Pleyer L, Egle A, Hartmann TN, Greil R.
Nat Rev Clin Oncol. 2009 Jul,6(7):405-18. doi: 10.1038/nrclinonc.2009.72. Epub 2009 Jun 2.
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Initial evaluation of the Roche COBAS TaqMan HIV-1 v2.0 assay for determining viral load in HIV-infected individuals.
Taylor N, Schmid I, Egle A, Greil R, Patsch W, Oberkofler H.
Antivir Ther. 2009,14(8):1189-93. doi: 10.3851/IMP1427.
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PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia.
Holler C, Piñón JD, Denk U, Heyder C, Hofbauer S, Greil R, Egle A.
Blood. 2009 Mar 19,113(12):2791-4. doi: 10.1182/blood-2008-06-160713. Epub 2009 Jan 23.
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The REVLIRIT CLL5 AGMT Study - a Phase I/II Trial Combining Fludarabine/Rituximab with Escalating Doses of Lenalidomide Followed by Rituximab/Lenalidomide in Untreated Chronic Lymphocytic Leukemia (CLL): Results of a Planned Interim Analysis
Egle, A, Steurer, M, Melchardt, T, Stoll, M, Greil, R
BLOOD. 2009, 114(22): 1341-1342.
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The Inverse Correlation of Regulatory T Cells and Time to Initial Treatment in Chronic Lymphocytic B-Cell Leukemia
Weiss, L, Melchardt, T, Grabmer, C, Egle, A, Tinhofer, I, Greil, R
BLOOD. 2009, 114(22): 510-510.
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FINAL RESULTS OF ORAL FLUDARABINE WITH CONCOMITANT SUBCUTANEOUS ALEMTUZUMAB IN RELAPSED/REFRACTORY B-CHRONIC LYMPHOCYTIC LEUKAEMIA (B-CLL): THE FLUSALEM STUDY
Egle, A, Melchardt, T, Pleyer, L, Tinhofer, I, Lang, A, Keil, F, Thaler, J, Gunsilius, E, Fridrik, M, Greil, R
HAEMATOL-HEMATOL J. 2009, 94: 140-140.
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Minimal Residual Disease (MRD) and T/NK Cell Dynamics during Fludarabine, Cyclophosphamide Plus Rituximab (FCR) Followed by Fludarabine Plus Rituximab (FR) and Remission Maintenance Therapy with Rituximab in Previously Untreated B-Chronic Lymphocytic Leukemia (B-CLL): Riskfactor Stratification in the Chairos Study.
Egle, A, Weiss, L, Gassner, F, Russ, G, Pleyer, L, Gunsilius, E, Tinhofer, I, Thaler, J, Petzer, AL, Greil, R
BLOOD. 2008, 112(11): 1089-1089.
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T Cell Dynamics during the Pretumor and Tumor Phase in the Murine Tcll Transgenic Chronic Lymphocytic Leukemia Model
Egle, A, Pinon, JD, Heyder, C, Holler, C, Denk, U, Tinhofer, I, Greil, R
BLOOD. 2008, 112(11): 1078-1078.
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Bim and Bmf in tissue homeostasis and malignant disease.
Piñon JD, Labi V, Egle A, Villunger A.
Oncogene. 2008 Dec,27 Suppl 1:S41-52. doi: 10.1038/onc.2009.42.
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Planned first efficacy and safety analysis of de-intensified induction with fludarabine, cyclophosphamide plus rituximab (FCR) followed by fludarabine plus rituximab (FR) and remission maintenance therapy with rituximab in previously untreated B-chronic lymphocytic leukemia (B-CLL): The chairos study
Egle, A, Weiss, L, Russ, G, Thoedtmann, R, Pleyer, L, Gastl, G, Thaler, J, Petzer, A, Tinhofer, I, Greil, R
BLOOD. 2007, 110(11): 609A-609A.
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The effect of IgVH mutational status on the induction of apoptosis by rituximab in patients with heavily pretreated B-cell chronic lymphocytic leukemia: evidence from a clinical phase I/II trial.
Tinhofer I, Steurer M, Leitinger G, Rumpold H, Egle A, Erdel M, Greil R.
Haematologica. 2006 Sep,91(9):1291-3.
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Expression levels of CD38 in T cells predict course of disease in male patients with B-chronic lymphocytic leukemia.
Tinhofer I, Rubenzer G, Holler C, Hofstaetter E, Stoecher M, Egle A, Steurer M, Greil R.
Blood. 2006 Nov 1,108(9):2950-6. Epub 2006 Jul 6.
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Planned first safety and efficacy analysis of oral fludarabine combined with subcutaneous alemtuzumab in 2(nd) line therapy of B-chronic lymphocytic leukaemia (B-CLL): The FLUSALEM study.
Egle, A, Tinhofer, I, Russ, G, Rass, C, Greil, R
BLOOD. 2006, 108(11): 336B-336B.
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Expression levels of CD38 in tumor cells and T-cells are of prognostic value in B-CLL
Tinhofer, I, Rubenzer, G, Egle, A, Greil, R
BLOOD. 2005, 106(11): 347A-347A.
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Stepping up treatment with Rituxan (R) (rituximab, Mabthera (R)) for CLL patients with advanced stage of disease relapsing after or refractory to conventional chemotherapy.
Greil, R, Steurer, M, Egle, A, Stauder, R, Anether, G, Ulmer, L, Tinhofer, I, Gastl, G
BLOOD. 2001, 98(11): 289B-290B.
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Analysis of Bcl-2 protein expression in chronic lymphocytic leukemia. A comparison of three semiquantitation techniques.
Marschitz I, Tinhofer I, Hittmair A, Egle A, Kos M, Greil R.
Am J Clin Pathol. 2000 Feb,113(2):219-29.
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Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma.
Tinhofer I, Marschitz I, Henn T, Egle A, Greil R.
Blood. 2000 Jan 15,95(2):610-8.
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On the role and significance of Fas (Apo-1/CD95) ligand (FasL) expression in immune privileged tissues and cancer cells using multiple myeloma as a model.
Greil R, Egle A, Villunger A.
Leuk Lymphoma. 1998 Nov,31(5-6):477-90.
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Functional granulocyte/macrophage colony stimulating factor receptor is constitutively expressed on neoplastic plasma cells and mediates tumour cell longevity.
Villunger A, Egle A, Kos M, Egle D, Tinhofer I, Henn T, Uberall F, Maly K, Greil R.
Br J Haematol. 1998 Sep,102(4):1069-80.
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Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia.
Tinhofer I, Marschitz I, Kos M, Henn T, Egle A, Villunger A, Greil R.
Blood. 1998 Jun 1,91(11):4273-81.
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Inversion of CD4(+)/CD8(+) ratio in B chronic lymphocytic leukemia correlates with differential sensitivity of CD4(+) and CD8(+) T lymphocytes to the killing efficacy of Fas (APO-1/CD95) ligand(+) tumor cells.
Tinhofer, I, Marschitz, I, Kos, M, Henn, T, Egle, A, Villunger, A, Greil, R
BLOOD. 1998, 92(10): 271B-271B.
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Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells.
Villunger A, Egle A, Kos M, Hartmann BL, Geley S, Kofler R, Greil R.
Cancer Res. 1997 Aug 15,57(16):3331-4.
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The interleukin 1beta-converting enzyme inhibitor CrmA prevents Apo1/Fas- but not glucocorticoid-induced poly(ADP-ribose) polymerase cleavage and apoptosis in lymphoblastic leukemia cells.
Geley S, Hartmann BL, Kapelari K, Egle A, Villunger A, Heidacher D, Greil R, Auer B, Kofler R.
FEBS Lett. 1997 Jan 27,402(1):36-40.
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Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance.
Villunger A, Egle A, Marschitz I, Kos M, Böck G, Ludwig H, Geley S, Kofler R, Greil R.
Blood. 1997 Jul 1,90(1):12-20.
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Expression of Apo-1/Fas (CD95), Bcl-2 Bax and Bcl-x in myeloma cell lines: relationship between responsiveness to anti-Fas mab and p53 functional status.
Egle A, Villunger A, Marschitz I, Kos M, Hittmair A, Lukas P, Grünewald K, Greil R.
Br J Haematol. 1997 May,97(2):418-28.
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Fas (Apo-1/CD95) - Ligand expression on neoplastic plasma cells and its role for the expansion of the neoplastic clone.
Greil, R, Villunger, A, Egle, A, Marschitz, L, Kos, M, Bock, G, Ludwig, H, Geley, S, Kofler, R
BLOOD. 1997, 90(10): 1578-1578.
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Modulation of Apo-1/Fas (CD95)-induced programmed cell death in myeloma cells by interferon-alpha 2.
Egle A, Villunger A, Kos M, Böck G, Gruber J, Auer B, Greil R.
Eur J Immunol. 1996 Dec,26(12):3119-26.
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IL-10 serum levels in B-cell chronic lymphocytic leukaemia.
Egle A, Marschitz I, Posch B, Herold M, Greil R.
Br J Haematol. 1996 Jul,94(1):211-2.
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2',2'-Difluorodeoxycytidine (gemcitabine) induces apoptosis in myeloma cell lines resistant to steroids and 2-chlorodeoxyadenosine (2-CdA).
Gruber J, Geisen F, Sgonc R, Egle A, Villunger A, Boeck G, Konwalinka G, Greil R.
Stem Cells. 1996 May,14(3):351-62.
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Constituents of autocrine IL-6 loops in myeloma cell lines and their targeting for suppression of neoplastic growth by antibody strategies.
Villunger A, Egle A, Kos M, Hittmair A, Maly K, Greil R.
Int J Cancer. 1996 Feb 8,65(4):498-505.
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Recombinant human erythropoietin in the anemia associated with multiple myeloma or non-Hodgkin's lymphoma: dose finding and identification of predictors of response.
Cazzola M, Messinger D, Battistel V, Bron D, Cimino R, Enller-Ziegler L, Essers U, Greil R, Grossi A, Jäger G, LeMevel A, Najman A, Silingardi V, Spriano M, van Hoof A, Ehmer B.
Blood. 1995 Dec 15,86(12):4446-53.
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