Assoc.Prof. Dr.
Tanja N. HartmannPriv. Doz. Dr. Tanja N. Hartmann

Deputy Head of the LIMCR, Group leader


Research focus

Malignant and normal cell trafficking, B-cell neoplasia, chemokines, integrins, extravasation, homing, adhesion

 

01/2009 onwards

Deputy Head of the Laboratory for Immunological and Molecular Cancer Research, Third Medical Department, Paracelsus Medical University, Salzburg, Austria.

 

03/2008 onwards

Group leader “CLL Trafficking” at the Laboratory for Immunological and Molecular Cancer Research (Head Prof. Richard Greil), Third Medical Department, Paracelsus Medical University, Salzburg, Austria.

 

02/2006 - 02/2008

Minerva postdoctoral fellow, Weizmann Institute of Science, Rehovot, Israel, Department of Immunology, group of Prof. Ronen Alon, Investigation of chemokine-integrin signaling at endothelial and extravascular contacts.

 

07/2002 - 02/2006

Postdoctoral fellow, Freiburg University Hospital, Germany, Department of Internal Medicine, group of Meike and Jan Burger, Investigation of the function of chemokine receptors in tumor progression and chemoresistance.

 

07/1999 - 06/2002

Ph. D student, University of Freiburg, Germany; Institute of Tree Physiology, Faculty of Forestry, Degree: Ph. D. in Biological Sciences, Supervision of Heinz Rennenberg, Thesis: “Regulation of glutathione biosynthesis in poplars”.

 

10/1993 - 05/1999

Faculty of Biology, University of Freiburg, Germany. Degree: Diploma in Biology

 

Research Grants

 

07/2014 - 06/2015

Research Fund from the Paracelsus Medical University (PMU-FFF # E-13/18/093-HAR), for the project “How does trisomy 12 switch CLL homing to the bone marrow from a CXCR4-dependent to a CXCR4-independent process”.

 

01/2014 - 12/2016

FWF Grant P26421-B13 for the project “The role of the integrin-linked kinase in normal and malignant B lymphocytes”.

 

10/2013 - 10/2015

Research Fund from the Monika Kutzner Stiftung for the collaborative project “Die Rolle des atypischen Chemokin-Rezeptors CRAM in der Chronisch Lymphatischen Leukämie“ by Tanja Hartmann and Meike Burger, Freiburg, Germany (equal contributions).

 

11/2012 - 04/2014

Research Fund from the Paracelsus Medical University (PMU-FFF # E-12/15/074-HAH), for the project “Alterations in chemokine and beta1 integrin induced Rac signaling in chronic lymphocytic leukaemia”.

 

08/2012 - 08/2016

FWF Grant P25015-B13 for the project “The role of CD44-hyaluronan interactions in the pathophysiology of chronic lymphocytic leukemia”.

 

10/2010 - 08/2012

Research Fund from the Paracelsus Medical University (PMU-FFF # E-10/11/058-HAR), for the project “The role of integrin-linked kinase in B-cell chronic lymphocytic leukaemia”, completed.

 

07/2009 - 07/2012

Grant (“Jubiläumsfond”) of the Österreichische Nationalbank (OeNB) for the project OeNB13420 “The role of the VLA-4 integrin in adhesion and survival of chronic lymphocytic leukemia cells”, completed.

 

02/2006 - 02/2008

Minerva (Max Planck) postdoctoral fellowship in the Weizmann Institute of Science, Israel, for the project “The role of VLA-4 and LFA-1 in the adhesion, locomotion and transendothelial migration of non-malignant and malignant B cells”, completed.

 

Feb 2006 - Feb 2008
Stipendiat der Minerva-Stiftung (Max-Planck-Gesellschaft, Deutschland)

 

Awards

June 2010

“Researcher of the year 2009”, Paracelsus Private Medical University Salzburg

  • 2017

    Reactivation of dormant anti-tumor immunity - a clinical perspective of therapeutic immune checkpoint modulation.

    Greil, R, Hutterer, E, Hartmann, TN, Pleyer, L.
    Cell Commun Signal. 2017, 15(1): 5.

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  • 2017

    Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signaling.

    Aberger, F, Hutterer, E, Sternberg, C, Del Burgo, PJ, Hartmann, TN.
    Cell Commun Signal. 2017, 15(1): 8.

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  • 2016

    Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones.

    Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
    Oncotarget. 2016, xx.

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  • 2016

    BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia.

    Haerzschel, A, Catusse, J, Hutterer, E, Paunovic, M, Zirlik, K, Eibel, H, Krenn, PW, Hartmann, TN, Burger, M.
    Ann Hematol. 2016, 95(12):197-1988.

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  • 2016

    Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

    Shatirishvili, M, Burk, AS, Franz, CM, Pace, G, Kastilan, T, Breuhahn, K, Hinterseer, E, Dierich, A, Bakiri, L, Wagner, EF, Ponta, H, Hartmann, TN, Tanaka, M, Orian-Rousseau, V.
    Cell Death Dis. 2016, 7(11):e2461.

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  • 2016

    CD44: More than a mere stem cell marker.

    Morath, I, Hartmann, TN, Orian-Rousseau, V.
    Int J Biochem Cell Biol. 2016.

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  • 2016

    BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia.

    Haerzschel, A, Catusse, J, Hutterer, E, Paunovic, M, Zirlik, K, Eibel, H, Krenn, PW, Hartmann, TN, Burger, M.
    Ann Hematol. 2016, 95(12):197-1988.

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  • 2016

    Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

    Shatirishvili, M, Burk, AS, Franz, CM, Pace, G, Kastilan, T, Breuhahn, K, Hinterseer, E, Dierich, A, Bakiri, L, Wagner, EF, Ponta, H, Hartmann, TN, Tanaka, M, Orian-Rousseau, V.
    Cell Death Dis. 2016, 7(11):e2461.

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  • 2016

    CD44: More than a mere stem cell marker.

    Morath, I, Hartmann, TN, Orian-Rousseau, V.
    Int J Biochem Cell Biol. 2016.

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  • 2016

    NCCN-IPI score-independent prognostic potential of pretreatment uric acid levels for clinical outcome of diffuse large B-cell lymphoma patients.

    Benedetti, D, Tissino, E, Caldana, C, Dal Bo, M, Bomben, R, Marconi, D, Ganghammer, S, Zaja, F, Pozzato, G, Di Raimondo, F, Hartmann, TN, Del Poeta, G, VanMeter, A, Zucchetto, A, Espina, V, Liotta, L, Gattei, V.
    Leukemia. 2016, 30(2): 513-517.

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  • 2016

    Developing a cancer immunogene therapy approach for Epidermolysis bullosa-associated squamous cell carcinoma.

    Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
    Oncotarget. 2016.

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  • 2016

    Persistent CD49d engagement in circulating CLL cells: a role for blood-borne ligands?.

    Benedetti, D, Tissino, E, Caldana, C, Dal Bo, M, Bomben, R, Marconi, D, Ganghammer, S, Zaja, F, Pozzato, G, Di Raimondo, F, Hartmann, TN, Del Poeta, G, VanMeter, A, Zucchetto, A, Espina, V, Liotta, L, Gattei, V.
    Leukemia. 2016, 30(2): 513-517.

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  • 2016

    ILK Induction in Lymphoid Organs by a TNFα-NF-κB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia.

    Krenn, PW, Hofbauer, SW, Pucher, S, Hutterer, E, Hinterseer, E, Denk, U, Asslaber, D, Ganghammer, S, Sternberg, C, Neureiter, D, Aberger, F, Wickström, SA, Egle, A, Greil, R, Hartmann, TN.
    Cancer Res. 2016, 76(8):2186-2196.

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  • 2016

    The AKT1 isoform plays a dominant role in the survival and chemoresistance of chronic lymphocytic leukaemia cells.

    Hofbauer, SW, Krenn, PW, Piñόn Hofbauer, J, Pucher, S, Asslaber, D, Egle, A, Hartmann, TN, Greil, R.
    Br J Haematol. 2016, 172(5): 815-819.

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  • 2016

    Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors.

    Ganghammer, S, Gutjahr, J, Hutterer, E, Krenn, PW, Pucher, S, Zelle-Rieser, C, Jöhrer, K, Wijtmans, M, Leurs, R, Smit, MJ, Gattei, V, Greil, R, Hartmann, TN.
    Haematologica. 2016, 101(3):e99-e102.

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  • 2016

    Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones.

    Melchardt, T, Hufnagl, C, Weinstock, DM, Kopp, N, Neureiter, D, Tränkenschuh, W, Hackl, H, Weiss, L, Rinnerthaler, G, Hartmann, TN, Greil, R, Weigert, O, Egle, A.
    Oncotarget. 2016.

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  • 2015

    The Role of CD44 in the Pathophysiology of Chronic Lymphocytic Leukemia.

    Gutjahr, JC, Greil, R, Hartmann, TN.
    FRONT IMMUNOL. 2015, 6: 177.

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  • 2015

    CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.

    Kocher, T, Asslaber, D, Zaborsky, N, Flenady, S, Denk, U, Reinthaler, P, Ablinger, M, Geisberger, R, Bauer, JW, Seiffert, M, Hartmann, TN, Greil, R, Egle, A, Hofbauer, JP.
    Leukemia. 2015, xx.

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  • 2015

    VLA-4 and CXCR4 overexpression in bone marrow of an aleukemic B-cell acute lymphoblastic leukemia presenting with osteolytic bone lesions.

    Hinterseer, E, Stiefel, O, Neureiter, D, Kandler, G, Vogt, S, Hutter, J, Strasser, G, Greil, R, Hartmann, TN, Hopfinger, G.
    Leuk Lymphoma. 2015, 56(8): 2465-2467.

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  • 2015

    CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation-dependent and -independent mechanisms.

    Hutterer, E, Asslaber, D, Caldana, C, Krenn, PW, Zucchetto, A, Gattei, V, Greil, R, Hartmann, TN.
    Br J Haematol. 2015, 169(2):286-289.

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  • 2015

    Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.

    Kern, D, Regl, G, Hofbauer, SW, Altenhofer, P, Achatz, G, Dlugosz, A, Schnidar, H, Greil, R, Hartmann, TN, Aberger, F.
    Oncogene. 2015, 34(42): 5341-5351.

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  • 2015

    B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia.

    Zaborsky, N, Holler, C, Geisberger, R, Asslaber, D, Gassner, FJ, Egger, V, Piñón-Hofbauer, J, Kocher, T, Hartmann, TN, Greil, R, Egle, A.
    Haematologica. 2015, 100(8): e307-e310.

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  • 2015

    Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2,5) translocation.

    Merkel, O, Hamacher, F, Griessl, R, Grabner, L, Schiefer, AI, Prutsch, N, Baer, C, Egger, G, Schlederer, M, Krenn, PW, Hartmann, TN, Simonitsch-Klupp, I, Plass, C, Staber, PB, Moriggl, R, Turner, SD, Greil, R, Kenner, L.
    J Pathol. 2015, 236(4): 44-56.

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  • 2015

    Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model.

    Gassner FJ, Zaborsky N, Catakovic K, Rebhandl S, Huemer M, Egle A, Hartmann TN, Greil R, Geisberger R.
    Br J Haematol. 2015 Aug,170(4):515-22. doi: 10.1111/bjh.13467. Epub 2015 May 4.

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  • 2015

    CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21.

    Ganghammer, S, Hutterer, E, Hinterseer, E, Brachtl, G, Asslaber, D, Krenn, PW, Girbl, T, Berghammer, P, Geisberger, R, Egle, A, Zucchetto, A, Kruschinski, A, Gattei, V, Chigaev, A, Greil, R, Hartmann, TN.
    Oncotarget. 2015, 6(14): 12048-12060.

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  • 2014

    Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia.

    Gassner FJ, Zaborsky N, Neureiter D, Huemer M, Melchardt T, Egle A, Rebhandl S, Catakovic K, Hartmann TN, Greil R, Geisberger R.
    Haematologica. 2014 May,99(5):67-9. doi: 10.3324/haematol.2013.098459. Epub 2014 Feb 21.

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  • 2014

    Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade.

    Grössinger EM, Weiss L, Zierler S, Rebhandl S, Krenn PW, Hinterseer E, Schmölzer J, Asslaber D, Hainzl S, Neureiter D, Egle A, Piñón-Hofbauer J, Hartmann TN, Greil R, Kerschbaum HH.
    Leukemia. 2014 Apr,28(4):954-8. doi: 10.1038/leu.2014.37. Epub 2014 Jan 20.

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  • 2014

    VLA-4 and CXCR4 overexpression in bone marrow of an aleukemic B-cell acute lymphoblastic leukemia presenting with osteolytic bone lesions.

    Hinterseer E, Stiefel O, Neureiter D, Kandler G, Vogt S, Hutter J, Strasser G, Greil R, Hartmann TN, Hopfinger G.
    Leuk Lymphoma. 2015 Feb 9:1-3. [Epub ahead of print]

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  • 2014

    CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation-dependent and -independent mechanisms.

    Hutterer E, Asslaber D, Caldana C, Krenn PW, Zucchetto A, Gattei V, Greil R, Hartmann TN.
    Br J Haematol. 2015 Apr,169(2):286-9. doi: 10.1111/bjh.13188. Epub 2014 Oct 17.

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  • 2014

    "The CXCR4 and adhesion molecule expression of CD34+ hematopoietic cells mobilized by on-demand"" addition of plerixafor to granulocyte-colony-stimulating factor."""

    Girbl T, Lunzer V, Greil R, Namberger K, Hartmann TN.
    Transfusion. 2014 Sep,54(9):2325-35. doi: 10.1111/trf.12632. Epub 2014 Mar 28.

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  • 2014

    Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility of chronic lymphocytic leukemia cells.

    Hofbauer SW, Krenn PW, Ganghammer S, Asslaber D, Pichler U, Oberascher K, Henschler R, Wallner M, Kerschbaum H, Greil R, Hartmann TN.
    Blood. 2014 Apr 3,123(14):2181-8. doi: 10.1182/blood-2013-08-523563. Epub 2014 Feb 5.

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  • 2014

    The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia.

    Brachtl G, Piñón Hofbauer J, Greil R, Hartmann TN.
    Ann Hematol. 2014 Mar,93(3):361-74. doi: 10.1007/s00277-013-1967-y. Epub 2013 Nov 28.

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  • 2014

    CLL cells under flow.

    Hartmann TN
    Blood. 2014 Jun 5,123(23):3533-4. doi: 10.1182/blood-2014-04-565358. Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia. [Blood. 2014]

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  • 2013

    Blockade of the Potassium Channel KCa3.1 inhibits proliferation in Chronic Lymphocytic Leukemia

    Grossinger, EM, Weiss, L, Zierler, S, Hinterseer, E, Schmolzer, J, Asslaber, D, Hainzl, S, Egle, A, Pinon, JD, Hartmann, TN, Greil, R, Kerschbaum, HH
    ONKOLOGIE. 2013, 36: 191-192.

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  • 2013

    The transcription factor IRF-4 is related to prognosis in Chronic Lymphocytic Leukemia (CLL) and involved in proliferation and survival

    Asslaber, D, Hofbauer, JP, Zaborsky, N, Kocher, T, Hartmann, TN, Greil, R, Egle, A
    ONKOLOGIE. 2013, 36: 222-223.

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  • 2013

    Mimicking the microenvironment in chronic lymphocytic leukaemia - where does the journey go?

    Asslaber D, Grössinger EM, Girbl T, Hofbauer SW, Egle A, Weiss L, Greil R, Hartmann TN.
    Br J Haematol. 2013 Mar,160(5):711-4. doi: 10.1111/bjh.12151. Epub 2012 Dec 4.

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  • 2013

    Antiapoptotic effects of p21 regarding its subcellular localization in arsenic trioxide induced apoptosis in CLL

    Sifft, E, Hofbauer, JP, Asslaber, D, Hartmann, TN, Merkel, O, Greil, R
    ONKOLOGIE. 2013, 36: 222-222.

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  • 2013

    CXCR3 modulates CXCL12-mediated cellular responses in chronic lymphocytic leukemia

    Ganghammer, S, Hinterseer, E, Johrer, K, Greil, R, Hartmann, TN
    CYTOKINE. 2013, 63(3): 264-264.

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  • 2013

    Tiam1/Rac1 signals contribute to CLL cell proliferation and chemoresistance

    Hofbauer, SW, Krenn, PW, Ganghammer, S, Asslaber, D, Pichler, U, Wallner, M, Henschler, R, Greil, R, Hartmann, TN
    ONKOLOGIE. 2013, 36: 56-56.

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  • 2013

    CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCL21-induced motility.

    Girbl T, Hinterseer E, Grössinger EM, Asslaber D, Oberascher K, Weiss L, Hauser-Kronberger C, Neureiter D, Kerschbaum H, Naor D, Alon R, Greil R, Hartmann TN.
    Cancer Res. 2013 Jan 15,73(2):561-70. doi: 10.1158/0008-5472.CAN-12-2749. Epub 2012 Nov 1.

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  • 2013

    CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism.

    Zucchetto A, Caldana C, Benedetti D, Tissino E, Rossi FM, Hutterer E, Pozzo F, Bomben R, Dal Bo M, D'Arena G, Zaja F, Pozzato G, Di Raimondo F, Hartmann TN, Rossi D, Gaidano G, Del Poeta G, Gattei V.
    Blood. 2013 Nov 7,122(19):3317-21. doi: 10.1182/blood-2013-06-507335. Epub 2013 Sep 25.

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  • 2012

    Canonical and noncanonical Hedgehog/GLI signaling in hematological malignancies.

    Aberger F, Kern D, Greil R, Hartmann TN.
    Vitam Horm. 2012,88:25-54. doi: 10.1016/B978-0-12-394622-5.00002-X.

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  • 2012

    Chemokine-dependent B cell-T cell interactions in chronic lymphocytic leukemia and multiple myeloma - targets for therapeutic intervention?

    Jöhrer K, Hofbauer SW, Zelle-Rieser C, Greil R, Hartmann TN.
    Expert Opin Biol Ther. 2012 Apr,12(4):425-41. doi: 10.1517/14712598.2012.664128. Epub 2012 Feb 15.

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  • 2011

    Fludarabine modulates composition and function of the T cell pool in patients with chronic lymphocytic leukaemia.

    Gassner FJ, Weiss L, Geisberger R, Hofbauer JP, Egle A, Hartmann TN, Greil R, Tinhofer I.
    Cancer Immunol Immunother. 2011 Jan,60(1):75-85. doi: 10.1007/s00262-010-0920-3. Epub 2010 Sep 21.

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  • 2011

    Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells.

    Brachtl G, Sahakyan K, Denk U, Girbl T, Alinger B, Hofbauer SW, Neureiter D, Hofbauer JP, Egle A, Greil R, Hartmann TN.
    PLoS One. 2011,6(8):e23758. doi: 10.1371/journal.pone.0023758. Epub 2011 Aug 18.

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  • 2011

    CD44-hyaluronan interactions in the pathophysiology of chronic lymphocytic leukemia - regulation by cell activation

    Girbl, T, Asslaber, D, Brachtl, G, Denk, U, Weiss, L, Naor, D, Greil, R, Hartmann, TN
    ONKOLOGIE. 2011, 34: 140-140.

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  • 2010

    VLA-4 and CD38 in chronic lymphocytic leukemia - more than prognostic markers?

    Brechtl, G, Denk, U, Pinon-Hofbauer, JD, Greil, R, Hartmann, TN
    ONKOLOGIE. 2010, 33: 201-202.

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  • 2010

    The role of the VLA-4 integrin in adhesion and survival of chronic lymphocytic leukemia (CLL) cells

    Sahakyan, K, Hofbauer, S, Brachtl, G, Girbl, T, Henschler, R, Greil, R, Hartmann, TN
    ONKOLOGIE. 2010, 33: 201-201.

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  • 2010

    Modifying akt signaling in B-cell chronic lymphocytic leukemia cells.

    Hofbauer SW, Piñón JD, Brachtl G, Haginger L, Wang W, Jöhrer K, Tinhofer I, Hartmann TN, Greil R.
    Cancer Res. 2010 Sep 15,70(18):7336-44. doi: 10.1158/0008-5472.CAN-09-4411. Epub 2010 Sep 7.

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  • 2010

    Inhibition of GLI, but not Smoothened induces apoptosis in chronic lymphocytic leukemia cells.

    Desch P, Asslaber D, Kern D, Schnidar H, Mangelberger D, Alinger B, Stoecher M, Hofbauer SW, Neureiter D, Tinhofer I, Aberger F, Hartmann TN, Greil R.
    Oncogene. 2010 Sep 2,29(35):4885-95. doi: 10.1038/onc.2010.243. Epub 2010 Jul 5.

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  • 2010

    Erforschung der Chronisch Lymphatischen Leukämie am LIMCR.

    Hartmann TN.
    Med.ium. 6/2010.

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  • 2010

    ÖGHO-Frühjahrstagung: Chronische Lymphatische Leukämie, Adhäsionsmoleküle als mögliche therapeutische Ziele.

    Hartmann TN.
    JATROS Haematologie und Onkologie. 3/2010, Seite 63-65.

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  • 2010

    CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B.

    Leick M, Catusse J, Follo M, Nibbs RJ, Hartmann TN, Veelken H, Burger M.
    mmunology. 2010 Apr,129(4):536-46. doi: 10.1111/j.1365-2567.2009.03209.x. Epub 2009 Dec 2.

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  • 2009

    Novel therapeutics approaches to chronic lymphocytic leukemia based on recent biological insights.

    Hartmann TN, Pleyer L, Desch P, Egle A, Greil R.
    Discov Med. 2009 Oct,8(42):157-64.

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  • 2009

    Molecular and cellular mechanisms of CLL: novel therapeutic approaches.

    Pleyer L, Egle A, Hartmann TN, Greil R.
    Nat Rev Clin Oncol. 2009 Jul,6(7):405-18. doi: 10.1038/nrclinonc.2009.72. Epub 2009 Jun 2.

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  • 2009

    Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow.

    Hartmann TN, Grabovsky V, Wang W, Desch P, Rubenzer G, Wollner S, Binsky I, Vallon-Eberhard A, Sapoznikov A, Burger M, Shachar I, Haran M, Honczarenko M, Greil R, Alon R.
    Cancer Res. 2009 Apr 1,69(7):3121-30. doi: 10.1158/0008-5472.CAN-08-4136. Epub 2009 Mar 17.

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  • 2008

    A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells.

    Hartmann TN, Grabovsky V, Pasvolsky R, Shulman Z, Buss EC, Spiegel A, Nagler A, Lapidot T, Thelen M, Alon R.
    J Leukoc Biol. 2008 Oct,84(4):1130-40. doi: 10.1189/jlb.0208088. Epub 2008 Jul 24.

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Tel: +43-(0)57255-25845

Fax: +43-(0)57255-25998

Email: tanjanhartmann@gmail.com

 

Responsibility:

LIMCR: Deputy Head of the LIMCR

LIMCR: Group leader CLL Cell Trafficking and Microenvironment